脂蛋白a与脑小血管病变合并认知功能障碍的相关性研究  

Study on the correlation between lipoprotein(a)and cerebral small vessel disease with cognitive dysfunction

作　　者：窦荣花[1] 王雯[1] 邱志新[2] 许晓冬[2] 景海芳 王雪静 王爱卿[1] DOU Ronghua;WANG Wen;QIU Zhixin;XU Xiaodong;JING Haifang;WANG Xuejing;WANG Aiqing(Department of Neurology,Cangzhou Hospital of Integrated Chinese and Western Medicine,Cangzhou,Hebei,China,061001;Department of Neurological Rehabilitation,Cangzhou Hospital of Integrated Chinese and Western Medicine,Cangzhou,Hebei,China,061001)

机构地区：[1]河北省沧州中西医结合医院神经内科,河北沧州061001 [2]河北省沧州中西医结合医院神经康复科,河北沧州061001

出　　处：《分子诊断与治疗杂志》2021年第4期586-589,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河北省医学科学研究重点课题(20171192)。

摘　　要：目的探讨脂蛋白a(Lp(a))与脑小血管病变(CSVD)合并认知功能障碍的相关性。方法选择2012年1月至2017年1月本院收治的200例CSVD患者的临床资料,根据是否合并认知功能障碍分为A组(148例,合并认知功能障碍)、B组(52例,未合并认知功能障碍),并选取100例同期体检正常者纳入健康对照组,采用免疫透射比浊法测定3组患者血清Lp(a)水平,并比较3组患者简易精神状态评价量表(MMSE)、蒙特利尔认知评估量表(MoCA)、生活能力评估表(ADL)与Lp(a)相关性。结果3组患者的空间与执行能力、注意力、语言能力、抽象能力、命名能力、延迟记忆能力、定向力等MoCA各子项及MoCA总分比较:A组<B组<对照组,差异有统计学意义(P<0.05)。3组受检者血清Lp(a)比较:A组>B组>对照组,差异有统计学意义(P<0.05);ADL评分、MMSE评分比较:A组<B组<对照组,差异有统计学意义(P<0.05)。Lp(a)与MoCA评分、MMSE评分、ADL评分明显负相关(r_(1)=-0.237、r_(2)=-0.214、r_(3)=-0.305,P<0.05)。结论 Lp(a)升高促进CSVD患者认知功能障碍,与患者认知功能障碍程度负相关性。Objective To investigate the correlation between lipoprotein(a)(Lp(a))and cerebral small vessel disease(CSVD)with cognitive dysfunction. Methods The clinical data of 200 patients with CSVD admitted to our hospital from January 2012 to January 2017 were retrospectively analyzed. According to whether they were combined with cognitive dysfunction,they were divided into group A(148 cases with cognitive dysfunction)and group B(52 cases,without cognitive dysfunction),and 100 patients with normal physical examination during the same period were selected into the healthy control group. Serum Lp(a)levels of the three groups of patients were measured by immunoturbidimetric method. The three groups of patients with the Mini Mental State Evaluation Scale(MMSE),the Montreal Cognitive Assessment Scale(MoCA),the Living Ability Assessment Scale(ADL)and the correlation with Lp(a)were compared and analyzed. Results The spatial and executive ability,attention,language ability,abstract ability,naming ability,delayed memory ability,orientation ability and the total scores of MoCA of the patients in groups A and B were lower than those in the control group,and group A was lower than group B,the difference was statistically significant (P<0.05);the serum Lp(a)level of patients in groups A and B was higher than that in the control group,and group A was higher than that in group B,the difference was statistically significant(P<0.05);The scores of ADL and MMSE in group B were lower than those in the control group,and group A was lower than group B,the difference was statistically significant(P<0.05);Lp(a)was significantly negatively correlated with Mo CA score,MMSE score,and ADL score(r1=-0.237,r2=-0.214,r3=-0.305,P<0.05). Conclusion Elevated Lp(a)promotes cognitive dysfunction in patients with CSVD and is negatively correlated with the degree of cognitive dysfunction in patients.

关 键 词：脂蛋白A 脑小血管病变 认知功能障碍 相关性 

分 类 号：R743[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]