dNLR、PLR对非小细胞肺癌根治术患者预后评估  

Evaluation of dNLR and PLR on the prognosis of patients undergoing radical resection of non-small cell lung cancer

作　　者：徐彪[1] 沙纪名[1] 赵旭东[1] 曹炜[1] 吴君旭[1] 周晓[1] 徐盛松[1] XU Biao;SHA Jiming;ZHAO Xudong;CAO Wei;WU Junxu;ZHOU Xiao;XU Shengsong(Department of Cardiothoracic Surgery,The Second Affiliated Hospital of Anhui Medical University,Anhui,Hefei,China,230000)

机构地区：[1]安徽医科大学第二附属医院心胸外科,安徽合肥230000

出　　处：《分子诊断与治疗杂志》2021年第4期598-601,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安庆市2018年第二批自筹经费科技计划项目(2018Z2019)。

摘　　要：目的探索术前中性粒细胞与淋巴细胞比例(dNLR)、血小板-淋巴细胞比值(PLR)对非小细胞肺癌根治术患者预后的评估价值。方法选取2016年4月至2019年3月期间本院收治的148例非小细胞肺癌根治术患者,根据术后预后情况分为预后良好组(n=98),预后不良组(n=50),经二元Logistic回归分析影响患者预后因素,再进行dNLR、PLR检测,用ROC曲线分析,各项预测方式判定患者预后价值性。结果经二元Logistic回归分析,dNLR≥1.53、PLR≥122是影响NSCLC患者预后的独立因子。经ROC曲线分析,dNLR预测的AUC为0.813,预测灵敏度80.6%,特异度82.0%;PLR预测的AUC为0.833,预测灵敏度82.7%,特异度84.0%;d NLR联合PLR预测AUC为0.970,预测灵敏度98.0%,特异度96.0%,均具有一定准确率。经Kaplan-Meier分析,高水平d NLR、PLR者的死亡率高于低水平dNLR、PLR者,差异有统计学意义(P<0.05)。结论 dNLR、PLR可作为评估非小细胞肺癌根治术患者预后重要参考指标。Objective To explore the preoperative neutrophil to lymphocyte ratio(dNLR)and platelet-lymphocyte ratio(PLR)in evaluating the prognosis of patients undergoing radical resection of nonsmall cell lung cancer.Methods A selection of 148 patients undergoing radical resection of non-small cell lung cancer admitted to our hospital from April 2016 to March 2019 were divided into a good prognosis group(n=98)and a poor prognosis group(n=50)according to the postoperative prognosis.After binary logistic regression analysis of factors affecting the patient.s prognosis,d NLR and PLR were detected,and ROC curve analysis was used to determine the prognostic value of the patients.Results After binary logistic regression analysis,dNLR≥1.53 and PLR≥122 are independent factors affecting the prognosis of NSCLC patients.According to ROC curve analysis,the AUC predicted by d NLR is 0.813,the prediction sensitivity is 80.6%,and the specificity is 82.0%;the AUC predicted by PLR is 0.833,the prediction sensitivity is 82.7%,and the specificity is 84.0%.The prediction AUC of dNLR combined with PLR is 0.970,the prediction sensitivity is98.0%,and the specificity is 96.0%,both of which have a certain accuracy.According to Kaplan-Meier analysis,the mortality of patients with high levels of d NLR and PLR was higher than that of patients with low levels of dNLR and PLR,and the difference was statistically significant(P<0.05).Conclusion dNLR and PLR can be used as important reference indicators for evaluating the prognosis of patients undergoing radical resection of non-small cell lung cancer.

关 键 词：生存期 血小板计数/淋巴细胞计数 非小细胞肺癌根治术 预后 预测 

分 类 号：R734.2[医药卫生—肿瘤]