首发抑郁症患者的生活质量与临床症状的相关性研究  

Association between quality of life and clinical symptoms in patients with the first-episode depression

作　　者：姜文慧 高成阁[1] 董莹莹[1] 李烨[1] 陈策[1] JIANG Wenhui;GAO Chengge;DONG Yingying;LI Ye;CHEN Ce(Department of Psychiatry,The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China)

机构地区：[1]西安交通大学第一附属医院精神心理卫生科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2021年第3期448-452,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.81771471)。

摘　　要：目的研究首发抑郁症患者的生活质量与临床症状之间的关联。方法按照严格的筛选及剔除标准,纳入首发未治疗的抑郁症患者(n=36)和接受药物治疗的抑郁症患者(n=71),并按照相应的入组标准纳入年龄、性别和教育相应的对照组(n=59)。采用世界卫生组织生存质量测定量表简表(World Health Organization Quality of Life—Brief,WHOQOL-BREF)和社会适应自我评价量表(The Social Adaptation Self-evaluation Scale,SASS)评估所有受试者,汉密尔顿抑郁量表(The Hamilton Depression Rating Scale,HAMD)、汉密尔顿焦虑量表(The Hamilton Anxiety Scale,HAMA)以及蒙哥马利-斯伯格抑郁评定量表(Montgomery-Asberg Depression Rating Scale,MADRS)对患者进行评估。结果各组之间年龄、教育程度未发现显著差异。首发组和治疗组抑郁症患者生活质量未发现显著性差异,且均明显低于对照组;相关分析发现,抑郁首发组及治疗组的生理、环境和生活质量总分与HAMD、HAMA、MADRS评分均呈负相关。SASS与生理、心理、环境和生活质量总分呈正相关。结论首发组和治疗组抑郁患者的生活质量及社会适应均明显下降,且抑郁症状越重,生活质量越差,而社会适应更好的患者,生活质量更好。Objective To study the relationship between quality of life and clinical symptoms of patients with the first-episode depression.Methods The untreated patients(n=36)with the first-episode depression and the depression patients(n=71)on drug treatment were included according to the strict screening and exclusion criteria.Subjects in control group(n=59),who matched in age,gender and education,were included according to the corresponding enrollment criteria.World Health Organization Quality of Life—Brief(WHOQOL-BREF)and The Social Adaptation Self-evaluation Scale(SASS)were used to evaluate all the subjects.The Hamilton Depression Rating Scale(HAMD),The Hamilton Anxiety Scale(HAMA)and Montgomery-Asberg Depression Rating Scale(MADRS)were used to evaluate the depressive patients.Results There was no significant difference in age or education level between all the groups.The quality of life was significantly lower in the first group and the treatment group than in the control group;no significant difference was found between patients in the two depression groups.Correlation analysis showed that the total scores of physiology,environment and quality of life in the first group and the treatment group were negatively correlated with HAMD,HAMA and MADRS.SASS was positively correlated with the total scores of physiology,psychology,environment and quality of life.Conclusion The quality of life and social adaptation of patients with the first-episode depression and those with depression after treatment were significantly reduced.More serious depression symptoms are linked to the worse quality of life,while better social adaptation is linked to the better quality of life.

关 键 词：抑郁症 生活质量 生活质量测定量表简表 汉密尔顿抑郁量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]