七种肿瘤相关自身抗体联合检测对肺癌的诊断价值  

Diagnostic value of combined detection of 7-tumor associated autoantibodies in lung cancer

作　　者：贺侠琴 王伟琦 邓凯[1] 张凯歌[1] HE Xiaqin;WANG Weiqi;DENG Kai;ZHANG Kaige(Department of Clinical Laboratory,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院检验科,陕西西安710061

出　　处：《中国医药科学》2021年第8期37-40,共4页China Medicine And Pharmacy

摘　　要：目的探讨七种肿瘤相关自身抗体(7-TAAB)联合检测对肺癌的诊断价值。方法选择2018年5月至2020年2月西安交通大学第一附属医院收治的肺癌组患者148例,所有病例均经病例组织学检查确诊;同时选择肺部良性疾病组患者35例,健康对照组152例。采用酶联免疫吸附试验(ELISA)方法检测各组CAGE、GAGE7、GBU4-5、MAGE A1、PGP9.5、SOX2、p53的表达水平,采用秩和检验进行统计学分析;应用受试者工作特征(ROC)曲线、敏感度和特异度综合分析7-TAAB单独及联合检测对全肺癌及不同组织分型肺癌的诊断价值,阳性率比较采用χ2检验。结果肺癌组7-TAAB水平高于健康对照组,差异有统计学意义(P<0.05);肺癌组与肺部良性疾病组比较,除GBU4-5外,其他6-TAAB水平差异均无统计学意义(P>0.05)。7-TAAB联合检测诊断肺癌的ROC曲线下面积(ROC-AUC)为0.766,敏感度为82.4%,特异度为55.1%,其敏感度和ROC-AUC明显高于7-TAAB单项检测;进一步分析表明,7-TAAB联合检测对小细胞肺癌和肺鳞癌的诊断价值均优于肺腺癌和全肺癌。7-TAAB联合检测在肺癌不同临床分期及不同病理类型间的阳性率比较,差异无统计学意义(P>0.05)。7-TAAB联合检测在肺癌组的阳性率明显高于健康对照组(χ2=57.993,P<0.05),与肺部良性疾病组比较,差异无统计学意义(χ2=3.371,P>0.05)。结论7-TAAB联合检测可为肺癌的诊断提供参考依据。Objective To investigate the diagnostic value of combined detection of 7-tumor associated autoantibodies(7-TAAB)in lung cancer.Methods Patients in diagnosed lung cancer group(n=148)admitted to our hospital from May 2018 to February 2020 were selected and researched retrospectively,all of which were confirmed by histological examination.Meanwhile,patients in the benign lung diseases group(n=35)and the healthy control group(n=152)were selected.Enzyme-linked immunosorbent assay(ELISA)was used to detect the expression levels of CAGE,GAGE7,GBU4-5,MAGE A1,PGP9.5,SOX2 and p53 in each group,and rank sum test was adopted for statistical analysis.The diagnostic value of 7-TAAB detection alone and in combination for whole lung cancer and lung cancer of different tissue types were comprehensively analyzed by applying receiver operating characteristics(ROC)curve,sensitivity and specificity.Chi-square test was used to compare the positive rates.Results The level of 7-TAAB in the lung cancer group was higher than that in the healthy control group,with statistically significant difference(P<0.05).There were no statistically significant differences in other 6-TAAB levels between the lung cancer group and the benign lung cancer group except GBU4-5(P>0.05).The area under the ROC curve(ROCAUC)of 7-TAAB combined detection in the diagnosis of lung cancer was 0.766,the sensitivity was 82.4%,and the specificity was 55.1%.Its sensitivity and ROC-AUC were significantly higher than that of 7-TAAB single detection.Further analysis showed that the diagnostic value of 7-TAAB combined detection in small cell lung cancer and lung squamous cell carcinoma was superior to that in lung adenocarcinoma and whole lung cancer.There were no statistically significant differences in the positive rate of 7-TAAB combined detection among different clinical stages and pathological types of lung cancer(P>0.05).The positive rate of 7-TAAB combined detection in the lung cancer group was significantly higher than that in the healthy control group(χ2=57.993,P<0.0

关 键 词：自身抗体 肺癌 联合检测 诊断 

分 类 号：R734.2[医药卫生—肿瘤]