长链非编码RNA调控血管新生的研究进展  

Research progress of long non-coding RNA involvement in angiogenesis

作　　者：王利然 杨丽红[1,3] 宁文华 秦懿囡 李晶 杜元灏[1,3] WANG Liran;YANG Lihong;NING Wenhua;QIN Yinan;LI Jing;DU Yuanhao(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;Institute of Acupuncture and Moxibustion,the First Teaching Hospital of Tianjin University of TCM,Tianjin 300381;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]天津中医药大学第一附属医院针灸研究所,天津300381 [3]国家中医针灸临床医学研究中心,天津300381

出　　处：《中国比较医学杂志》2021年第4期143-149,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然基金青年科学基金项目(81904292)。

摘　　要：血管新生与许多疾病密切相关,对疾病的发展及预后起到至关重要的作用。lncRNA是血管新生重要的调控分子,通过调控血管内皮细胞表型转变、血管内皮生长因子及miRNA的表达,参与缺血性脑卒中、肿瘤、动脉粥样硬化等疾病的病理恢复过程。文中综述了lncRNA的生物学功能及其在血管生成和血管疾病中的表达变化、调控作用的相关研究,以期为后续血管新生的机制研究及临床应用提供参考。Angiogenesis is closely related to many diseases and plays an important role in the development and prognosis of diseases.Long non-coding RNAs(lncRNAs)are important regulatory molecules of angiogenesis that are involved in the pathological recovery process of ischemic stroke,tumor,atherosclerosis and other diseases by regulating the phenotypic transformation of vascular endothelial cells,angiogenic factors and miRNA expression.Here,we review the biological functions of lncRNAs,and describe their expression and regulatory effects in angiogenesis and vascular diseases to provide reference for ongoing research into lncRNA mechanisms of action and their clinical application in angiogenesis.

关 键 词：长链非编码RNA 血管新生 血管内皮细胞 血管内皮生长因子 MIRNA 信号通路 

分 类 号：R-33[医药卫生]