桥本甲状腺炎合并甲状腺乳头状癌中环氧化酶-2的表达及临床意义  

Expression and clinical significance of cyclooxygenase-2 in Hashimoto′s thyroiditis complicated with papillary thyroid carcinoma

作　　者：杜佳伟 DU Jia-wei(Department of General Surgery,Bengang General Hospital of Liaoning Provincial Health Industry Group,Liaoning Province,Benxi117000,China)

机构地区：[1]辽宁省健康产业集团本钢总医院普外科,辽宁本溪117000

出　　处：《中国当代医药》2021年第13期38-41,共4页China Modern Medicine

摘　　要：目的探讨桥本甲状腺炎(HT)合并甲状腺乳头状癌(PTC)中环氧化酶-2(COX-2)的表达及临床意义,以期为临床诊疗提供指导。方法收集2019年7月~2020年7月辽宁省健康产业集团本钢总医院病理科85例HT合并PTC患者石蜡标本,检测COX-2的表达。比较癌组织和癌旁组织中COX-2的阳性表达率,分析患者临床资料,比较不同病理特征[肿瘤数目、肿瘤直径、TNM分期、包膜侵犯、淋巴结转移(LNM)]患者的癌组织中COX-2的阳性表达率。结果HT合并PTC患者癌组织COX-2阳性表达率高于癌旁组织,差异有统计学意义(P<0.05);有包膜侵犯的HT合并PTC患者癌组织COX-2阳性表达率高于无包膜侵犯患者,有LNM的HT合并PTC患者癌组织COX-2阳性表达率高于无LNM癌组织,差异有统计学意义(P<0.05);不同肿瘤数目、直径、TNM分期癌组织的COX-2阳性表达率比较,差异无统计学意义(P>0.05);经Logistic回归分析显示,COX-2表达阳性是HT合并PTC患者癌组织包膜侵犯、LNM的影响因素(OR>1,P<0.05)。结论COX-2异常高表达与HT合并PTC的病情发展密切相关,可能提示包膜侵犯及LNM的发生,可依据COX-2的表达情况预测HT合并PTC的病情严重程度。Objective To explore the expression and clinical significance of cyclooxygenase-2(COX-2)in Hashimoto′s thyroiditis(HT)combined with papillary thyroid carcinoma(PTC),in order to provide guidance for clinical diagnosis and treatment.Methods The paraffin specimens of 85 patients with HT and PTC in the Department of Pathology of Bengang General Hospital of Liaoning Health Industry Group from July 2019 to July 2020 were collected to detected the expression of COX-2.The positive expression rates of COX-2 in cancer tissues and adjacent tissues were compared,the clinical data of the patients were analyzed,the positive expression rate of COX-2 in cancer tissues of patients with different pathological characteristics[tumor number,tumor diameter,TNM stage,capsule invasion,lymph node metastasis(LNM)]were compared.Results The positive expression rate of COX-2 in cancer tissues of patients with HT combined with PTC was higher than that in adjacent tissues,the difference was significant statistically(P<0.05).The positive expression rate of COX-2 in HT and PTC patients with capsule invasion was higher than that in patients without capsule invasion,the positive expression rate of COX-2 in HT patients with PTC and LNM was higher than that in patients without LNM,the differences were statistically significant(P<0.05).There was no significant difference between the positive expression rate of COX-2 in cancer tissues of different tumor number,tumor diameter,TNM stage(P>0.05).Logistic regression analysis showed that the positive expression of COX-2 might be the influencing factor of capsule invasion and LNM in HT patients with PTC(OR>1,P<0.05).Conclusion The abnormally high expression of COX-2 is closely related to the disease development of HT combined with PTC,which may indicate the occurrence of LNM and capsule invasion.The severity of HT combined with PTC can be predicted based on the expression of COX-2.

关 键 词：桥本甲状腺炎 甲状腺乳状癌 环氧化酶-2 包膜侵犯 淋巴结转移 

分 类 号：R736.1[医药卫生—肿瘤]