白细胞介素-1β、肿瘤坏死因子-α在肠梗阻患者术前及术后血清中的变化  

Changes of interleukin-1βand tumor necrosis factor-αin serum of patients with intestinal obstruction before and after operation

作　　者：李新源 杜非 高枫 刘自强 吕婕 任丽芬 LI Xin-yuan;DU Fei;GAO Feng;LIU Zi-qiang;LYU Jie;REN Li-fen(Department of General Surgery,the First People′s Hospital of Longnan City,Gansu Province,Longnan746000,China;Department of Clinical Laboratory,Xijing Hospital of Air Force Military Medical University,Shaanxi Province,Xi′an710032,China)

机构地区：[1]甘肃省陇南市第一人民医院普外科,甘肃陇南746000 [2]空军军医大学西京医院检验科,陕西西安710032

出　　处：《中国当代医药》2021年第13期71-73,77,共4页China Modern Medicine

摘　　要：目的观察白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)在手术肠梗阻患者中的变化并探讨其意义。方法选取2016年8月~2018年8月于甘肃省陇南市第一人民医院住院的行手术治疗的40例肠梗阻患者作为研究对象,按照术中是否有肠坏死情况分为两组:单纯性肠梗阻组18例,绞窄性肠梗阻组22例。收集患者入院时及术后3、7 d清晨空腹外周静脉血,采用酶联免疫吸附测定(ELISA)检测血清中IL-1β、TNF-α的含量。结果两组患者的IL-1β在入院时、术后3 d及术后7 d三个时间点比较,差异有统计学意义(P<0.05);单纯性肠梗阻组及绞窄性肠梗阻组的IL-1β在每个时间点比较,差异有统计学意义(P<0.05);组别与时间的交互作用比较,差异有统计学意义(P<0.05)。两组患者的TNF-α在入院时、术后3 d及术后7 d三个时间点比较,差异有统计学意义(P<0.05);单纯性肠梗阻组及绞窄性肠梗阻组的TNF-α在每个时间点比较,差异有统计学意义(P<0.05);组别与时间的交互作用比较,差异有统计学意义(P<0.05)。结论肠梗阻患者血清中的IL-1β、TNF-α随着疾病的转归而下降,动态监测术后的IL-1β、TNF-α有助于了解肠梗阻患者的转归,并提示可能是肠梗阻发生绞窄的早期炎症细胞因子。Objective To observe the changes of interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)in patients with intestinal obstruction treated by operation and to explore the clinical significance.Methods A total of 40 patients with intestinal obstruction who were hospitalized in the First People′s Hospital of Longnan City,Gansu Province from August 2016 to August 2018 were selected as the research objects.According to whether there was intestinal necrosis during the operation,they were divided into two groups:simple intestinal obstruction group(18 cases)and strangulated intestinal obstruction group(22 cases).The fasting peripheral venous blood was collected at the time of admission and 3 and 7 days after the operation,and the serum levels of IL-1βand TNF-αwere detected by enzyme-linked immunosorbent assay(ELISA).Results The levels of IL-1βbetween the two groups were compared at the time of admission,3 d after operation,and 7 d after operation,the differences were statistically significant(P<0.05).The comparison of IL-1βbetween the simple intestinal obstruction group and the strangulated intestinal obstruction group at each time point was statistically significant(P<0.05).There was a statistically significant difference in the interaction between group and time in IL-1β(P<0.05).The levels of TNF-αbetween the two groups were compared at the time of admission,3 d after operation,and 7 d after operation,the differences were statistically significant(P<0.05).The comparison of TNF-αbetween the simple intestinal obstruction group and the strangulated intestinal obstruction group at each time point was statistically significant(P<0.05).There was a statistically significant difference in the interaction between group and time in TNF-α(P<0.05).Conclusion Serum IL-1βand TNF-αin patients with intestinal obstruction decrease with the disease progression.Dynamic monitoring of postoperative IL-1βand TNF-αhelps to understand the outcome of patients with intestinal obstruction and suggests that they may be intestin

关 键 词：肠梗阻 白细胞介素-1Β 肿瘤坏死因子-Α 单纯性肠梗阻 绞窄性肠梗阻 

分 类 号：R574[医药卫生—消化系统]