胃底贲门混合性鳞状细胞神经内分泌癌一例并文献复习  

Mixed Squamous Cell Neuroendocrine Carcinoma of Gastric Fundus and Cardia: A Case Reportand Literature Review

作　　者：卢腾飞 许芹芹 王俊萍[1] LU Teng-fei;XU Qin-qin;WANG Jun-ping(Department of Gastroenterology,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China;Department of Pathology,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China)

机构地区：[1]北京大学深圳医院消化内科,广东深圳518036 [2]北京大学深圳医院病理科,广东深圳518036

出　　处：《罕少疾病杂志》2021年第3期10-11,13,共3页Journal of Rare and Uncommon Diseases

摘　　要：神经内分泌肿瘤是起源于分布全身的神经内分泌细胞的少见肿瘤,2010年WHO将消化道神经内分泌肿瘤分为三类:神经内分泌瘤、神经内分泌癌、混合性腺神经内分泌癌,其中混合性腺神经内分泌癌是罕见、恶性程度极高的一类,病理诊断是“金标准”,免疫组化是病理诊断的重要补充及分级标准。本研究回顾性分析一例极其罕见的发生在胃底贲门的混合鳞癌成分的神经内分泌癌,并复习相关文献,以期提高对神经内分泌肿瘤的认识。Neuroendocrine neoplasm(NEN)are rare tumors originating from neuroendocrine cells distributed throughout the body.In 2010,WHO classified gastrointestinal NEN into three categories:neuroendocrine tumor(NET),neuroendocrine carcinoma(NEC)and mixed adenoneuroendocrine carcinoma(MANEC),of which MANEC is a rare type with extremely high malignancy.Pathological diagnosis is the gold standard,and immunohistochemistry is a crucial supplement and grading standard.This article retrospectively analyzed a rare case of NEC with mixed squamous cell carcinoma in the fundus and cardia of the stomach,and relevant literature was reviewed to improve the understanding of NEN.

关 键 词：癌 混合性腺神经内分泌 胃底贲门肿瘤 病例报告 

分 类 号：R573.7[医药卫生—消化系统]