Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats  

作　　者：Fan Zhang Ken K.L.Yung Chi KongYeung 

机构地区：[1]Division of Science and Technology,BNU-HKBU United International College,Zhuhai,Guangdong,China [2]Department of Biology,Hong Kong Baptist University,Hong Kong,China [3]Animal Science Department,California Polytechnic State University,San Luis Obispo,California,USA

出　　处：《Food Science and Human Wellness》2021年第3期327-334,共8页食品科学与人类健康（英文）

基　　金：The technical assistance provided by the staff at HKBU animal facilities is grateful acknowledged.This project was funded by the National Natural Science Foundation of China(award no.31171664).

摘　　要：Prebiotics may enhance iron absorption,and one plausible mechanism involves the production of shortchain fatty acids(SCFA)in the colon by intestinal microflora.The objectives of this study were to determine the effects of common commercially-available prebiotics including fructooligosaccharide(FOS),inulin,FOS-inulin mixture,galactooligosaccharide(GOS),and lactulose on the iron status of anemic rats,and to monitor changes in the production of colonic SCFA.Anemic Sprague-Dawley rats receiving a lowiron diet(12μg Fe/g diet)were supplemented with or without prebiotics(5%m/V in drinking water)for 5 weeks.Hemoglobin concentration in rats supplemented with GOS after 3 weeks(4.3 g/dL)was significantly higher than rats without supplementation(3.7 g/dL),while FOS also significantly increased hemoglobin concentration after 4 weeks(4.1 g/dL vs.3.7 g/dL).All other prebiotics showed no effects.Anemic rats showed lower overall SCFA production in the colon than normal rats,and only FOS signifi cantly increased the production of the three main SCFA(acetic acid,propionic acid and isobutyric acid)identifi ed in anemic rats,with other prebiotics showing no noticeable trends.Our results suggest that GOS and FOS may slightly improve iron status of anemic rats,but the role of SCFA in the colon is not clear.

关 键 词：IRON Non-digestible oligosaccharides Short-chain fatty acids PREBIOTICS Rat 

分 类 号：TS201.3[轻工技术与工程—食品科学]