Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice  

作　　者：Donglu Fang Dan Wang Gaoxing Ma Yang Ji Huihua Zheng Hui Chen Mingwen Zhao Qiuhui Hu Liyan Zhao 

机构地区：[1]College of Food Science and Technology,Nanjing Agricultural University/Key Laboratory of Edible Mushroom Processing,Ministry of Agriculture and Rural Affairs,Nanjing 210095,China [2]College of Food Science and Engineering,Nanjing University of Finance and Economics,Nanjing 210023,China [3]Jiangsu Alphay Bio-technology Co.,Ltd.,Nantong 226009,China [4]College of Life Sciences,Nanjing Agricultural University,Nanjing,Jiangsu 210095,China

出　　处：《Food Science and Human Wellness》2021年第4期431-441,共11页食品科学与人类健康（英文）

基　　金：This work was financially supported by the China Agriculture Research System(CARS-20);the Jiangsu Provincial Key Research and Development Program(BE2019323).

摘　　要：Auricularia polytricha possesses hypolipidemic effects and decreases lipid accumulation,leading to potential food additives for functional food processing.In this research,we explored the potential effects of A.polytricha noodles on hyperlipidemia and gut microbiota dysbiosis,and elucidated their possible regulatory mechanisms on lipid metabolism in high-fat diet(HFD)mice.A.polytricha n oodles treatment signifi cantly(P<0.05)reduced body weight gain,hyperlipidemia and liver fat accumulation.Meanwhile,A.polytricha noodles decreased the levels of serum total cholesterol(TC),total triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)compared with the HFD group.Furthermore,A.polytricha noodles could enrich the diversity of gut microbiota by decreasing the ratio of Firmicutes to Bacteroidetes as well as the relative abundance of Deferribacteres and increased the relative abundance of Verrucomicrobia,which might contribute to the prevention of hyperlipidemia.This study indicated that A.polytricha noodles could modulate the gut microbiota and prevent hyperlipidemia and liver fat accumulation induced by HFD.

关 键 词：Auricularia polytricha noodles HYPERLIPIDEMIA Lipid metabolism Gut microbiota 

分 类 号：TS213.24[轻工技术与工程—粮食、油脂及植物蛋白工程] TS219[轻工技术与工程—食品科学与工程]