The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice  

作　　者：Yange Liu Ronglong Chen Lanzhou Li Ruitao Dong Hui Yin Yawen Wang Anhui Yang Jianbin Wang Changtian Li Di Wang 

机构地区：[1]School of Basic Medical Sciences,Nanchang University,Nanchang 330038,China [2]School of Life Sciences,Jilin University,Changchun 130012,China [3]Department of Thoracic Surgery,The First Affi liated Hospital of Nanchang University,Nanchang 330006,China [4]Engineering Research Center of Edible and Medicinal Fungi,Ministry of Education,Jilin Agricultural University,Changchun 130118,China

出　　处：《Food Science and Human Wellness》2021年第4期497-507,共11页食品科学与人类健康（英文）

基　　金：This research was funded by the National Key Research&Development Program of China(grant number:2018YFE0107800);the Special Projects of the Cooperation between Jilin University and Jilin Province(grant number:SXGJXX2017-1);the Science and Technology Develop Project in Jilin Province of China under grant(No.20191102027YY,20200708091YY and 20200708068YY);Research and Cultivation Project for Young Teachers of Jiangxi Medical College,Nanchang University(No.PY201901).

摘　　要：The major pathologic hallmark of the alcoholic liver disease(ALD)is the representation of chronic alcohol-induced hepatocyte lipid accumulation.This study aims to investigate the hepatoprotective role of triterpenoids-enriched extracts from Antrodia cinnamomea mycelia(ACT)in chronic alcohol-induced liver injury mice,establishing in C57BL/6 mice through gradient alcohol feeding for 24 weeks.In longterm alcohol consumption mice,the significantly lost body weight,increased organ indexes,hepatic alanine aminotransferase and aspartate aminotransferase levels were all remissed after 6-week ACT orally administration,showing its hepatoprotective property.ACT suppressed the triglyceride,total cholesterol and low-density lipoprotein levels,and enhanced high-density lipoprotein levels in serum or/and liver of chronic alcohol damaged mice.Combining with the pathological observations,ACT displayed an anti-steatosis effects to restrain the progress of ALD.Based on proteomic analysis and enzyme-linked immunosorbent assay,ACT had been confi rmed to regulate the levels of lipid biogeneration-related factors and depressed the over-accumulation of hepatic reactive oxygen species.According to further data,ACT prevented alcoholic liver injury may be associated with mediating lipid metabolism-related to PGC-1αand NF-κB signaling.In summary,ACT protected the body against chronic alcohol ingest induced liver injury through its regulation lipid on metabolism.

关 键 词：An trodia cinnamomea mycelia TRITERPENOIDS Chronic alcohol-induced liver injury Lipid accumulation 

分 类 号：TS201.4[轻工技术与工程—食品科学]