老年重症肌无力诊治分析  

Clinical features of elderly patients with myasthenia gravis

作　　者：宋宣克[1] 王林景 冯怡锟[1] 张文强[1] 黄壮士[1] SONG Xuanke;WANG Linjing;FENG Yikun;ZHANG Wenqiang;HUANG Zhuangshi(The Second Affiliated Hospital of Zhengzhou Universsity,Zhengzhou 450003,China;College of Information Technology,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]郑州大学第二附属医院,河南郑州450003 [2]河南中医药大学信息技术学院,河南郑州450046

出　　处：《中国实用神经疾病杂志》2021年第9期765-769,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20190308)。

摘　　要：目的探讨老年重症肌无力(MG)的临床特点。方法回顾性分析2014-01—2020-01在郑州大学第二附属医院接受治疗的89例老年MG患者的临床资料。结果老年MG患者男女比例为1∶1.02。以OssermanⅠ型起病者44例,男24例(54.5%),女20例(45.5%);以OssermanⅡ型起病者43例,男18例(41.9%),女25例(58.1%);两种起病方式中男女患者所占比例差异无统计学意义(P=0.236);首诊被误诊17例(19.1%);合并甲状腺疾病14例(15.7%),合并胸腺异常42例(47.2%);术后病理分型以AB型胸腺瘤最多7例(24.1%),男∶女为2∶5;并发重症肌无力危象12例(13.5%)。结论老年MG有自己特点,临床工作中需提高对老年患者合并MG的认识。Objective To investigate the clinical features of elderly patients with myasthenia gravis.Methods The clinical data of 89 elderly patients with myasthenia gravis who were treated in the Second Affiliated Hospital of Zhengzhou University from January 2014 to January 2020 were retrospectively analyzed.Results Among those MG patients,the male to female ratio was 1∶1.02.There were 44 patients whose onset symptom as OssermanⅠ,and the ratio of male to female was as 24∶20.There were 43 patients whose onset symptom as OssermanⅡ,and the ratio of male to female was as 18:25.And there was no statistically significant differ⁃ence in the two group gender difference(P=0.236).A total of 17 cases were misdiagnosed,accounted for 19.1%in the first diagnosis.There were 14 MG patients combined with thyroid disease,accounted for15.7%.There were 42 MG patients combined with thymus disease,accounted for 47.2%,and the most frequent one was thymoma.The most common pathological type of thymoma after thymec⁃tomy was AB,accounted for 24.1%,and the ratio of male to female was as 2∶5.Patients who combined with myasthenic crisis were 12,accounted for 13.5%.Conclusion There are specific clinical features for elderly patients with myasthenia gravis.In clinical work,we should improve understanding better for the clinical characteristics of this kind of MG,and make full prepation in the therapy.

关 键 词：重症肌无力 胸腺瘤 肌无力危象 误诊 临床特点 

分 类 号：R746.1[医药卫生—神经病学与精神病学]