水通道蛋白4与阿尔茨海默病的关系研究进展  

Recent advance in relation of aquaporin 4 with Alzheimer's disease

作　　者：张爽 黄晓雪 闫露露 唐窈 吴军[1] Zhang Shuang;Huang Xiaoxue;Yan Lulu;Tang Yao;Wu Jun(Department of Neurology,First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,郑州450052

出　　处：《中华神经医学杂志》2021年第4期406-411,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(U1604181);河南省医学科技攻关计划联合共建项目(LHGJ20190078)。

摘　　要：阿尔茨海默病(AD)是一种以进行性认知功能障碍为主要表现的神经退行性疾病,严重危害人类健康,同时给社会与家庭造成沉重的负担。水通道蛋白4(AQP4)是哺乳动物脑中重要的水通道蛋白类型,越来越多的研究发现其在AD的发生与发展中发挥着重要作用。本文通过对AQP4的结构、分布及功能进行概述,并系统阐述其参与AD发病的多种途径,以期为AD的治疗提供参考和借鉴。Alzheimer's disease(AD)is a neurodegenerative disease mainly manifested by progressive cognitive impairment,which is seriously harmful to human health and causes a heavy burden to society and family.Aquaporin 4(AQP4)is an important type of aquaporins(AQPs)in mammalian brain,and more and more studies have found that it plays an important role in the occurrence and development of AD.In this paper,the structure,distribution and function of AQP4 are summarized,and various ways of its participation in the pathogenesis of AD are systematically described to provide reference for the treatment of AD.

关 键 词：阿尔茨海默病 水通道蛋白4 神经退行性疾病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]