脑卒中后认知障碍血液学生物标志物的研究进展  

Recent advances in blood biomarkers of post-stroke cognitive impairment

作　　者：左洪州 褚堃 唐玲 赵思斯 卜晓青 Zuo Hongzhou;Chu Kun;Tang Ling;Zhao Sisi;Bu Xiaoqing(Department of Epidemiology,School of Public Health and Management,Chongqing Medical University,Chongqing 400016,China;Department of Neurology,University-Town Hospital of Chongqing Medical University,Chongqing 401331,China)

机构地区：[1]重庆医科大学公共卫生与管理学院流行病学教研室,重庆400016 [2]重庆医科大学附属大学城医院神经内科,重庆401331

出　　处：《中华神经医学杂志》2021年第4期412-416,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(81803309);重庆市教育委员会科学技术研究项目(KJQN201800441)。

摘　　要：脑卒中后认知障碍(PSCI)是脑卒中后的常见并发症,严重影响着患者的功能恢复。PSCI的临床诊断目前主要依靠影像学检查和神经心理学量表,但这些诊断方法具有一定局限性。血液学生物标志物获取相对方便且检测较为简单,更适合临床应用。随着分子生物学的不断发展,越来越多的研究表明各种神经损伤、炎症、氧化应激等标志物均在PSCI的发生发展过程中发挥重要作用。笔者现围绕PSCI血液学生物标志物的研究现状及其作用机制进行综述,并展望这些标志物在PSCI的预测和早期诊断中的应用前景。Post-stroke cognitive impairment(PSCI)is a kind of common complications after stroke,which seriously affects the functional recovery.The diagnosis of PSCI mainly depends on imaging measures and scale assessments at present,but these methods have some limitations.Blood samples are relatively convenient to collect for biomarker detection,and uitable for practical application in a clinical setting.Along with a remarkable development of molecular biology,increasing studies have shown that biomarkers of neuroinjury,inflammation and oxidative stress have played important roles in the development and progression of PSCI.Herein we review the progress and pathogenesis of blood biomarkers for PSCI,and the application of these biomarkers in prevention and early diagnosis of PSCI.

关 键 词：脑卒中 认知障碍 生物标志物 血液 

分 类 号：R743.3[医药卫生—神经病学与精神病学]