水通道蛋白4抗体阳性视神经脊髓炎谱系疾病的发病机制研究进展  

Recent advance in pathogenesis of aquaporin-4 immunoglobulin G positive neuromyelitis optica spectrum disorder

作　　者：李静[1] 刘家伶 林永忠[1] Li Jing;Liu Jialing;Lin Yongzhong(Department of Neurology,Second Affiliated Hospital of Dalian Medical University,Dalian 116023,China)

机构地区：[1]大连医科大学附属第二医院神经内科,大连116023

出　　处：《中华神经医学杂志》2021年第4期422-426,共5页Chinese Journal of Neuromedicine

基　　金：大连创新基金应用基础研究(2020JJ26SN054)。

摘　　要：视神经脊髓炎谱系疾病(NMOSD)主要包括急性脊髓炎、视神经炎和最后区综合征,其中水通道蛋白4(AQP4)-IgG阳性NMOSD患者较阴性患者症状更严重,复发更频繁,恢复更不完全,早期即可致残,但其确切发病机制尚不明确。本文现围绕AQP4-IgG阳性NMOSD发病机制的最新研究进展综述如下。Neuromyelitis optica spectrum disorder(NMOSD)is a central nervous system inflammatory disease characterized by aquaporin-4 immunoglobulin G(AQP4-IgG).The core clinical manifestations include acute myelitis,optic neuritis and area postrema syndrome.AQP4-IgG-positive NMOSD patients have severe symptoms,frequent relapses,less complete recovery and early disability.In recent years,AQP4-IgG-positive NMOSD has gradually been recognized,but its exact mechanism is still unclear.This paper reviews the recent advance in pathogenesis of AQP4-IgG positive NMOSD.

关 键 词：视神经脊髓炎谱系疾病 水通道蛋白4 水通道蛋白4抗体 

分 类 号：R744.52[医药卫生—神经病学与精神病学]