穴位埋线结合健脾疏肝法治疗肝郁脾虚证腹泻型肠易激综合征疗效观察及安全性评价  

Clinical observation and safety evaluation of acupoint embedding combined with soothing the liver and strengthening the spleen in the treatment of irritable bowel syndrome-diarrheal of liver depression and spleen deficiency

作　　者：魏景景[1] 郝莉莉[1] 王红霞[1] 康洪昌[1] 王威[1] 岳妍[1] WEI Jingjing;HAO Lili;WANG Hongxia;KANG Hongchang;WANG Wei;YUE Yan(Gastroenterology Department,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院消化科,天津300193

出　　处：《天津中医药》2021年第5期620-624,共5页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津中医药大学第一附属医院“拓新工程”基金科研课题(201412)。

摘　　要：[目的]观察穴位埋线结合健脾疏肝法对肝郁脾虚证腹泻型肠易激综合征(IBS)患者的临床疗效及安全性。[方法]将2018年4—6月间符合筛查标准的40例患者按随机数字表法均分为2组,每组各20例。对照组予中药汤剂口服,早晚各1袋,连续服用两周;治疗组予中药汤剂口服配合穴位埋线治疗,每周1次,连续治疗2周。分别于治疗前及2周后对两组患者进行IBS症状严重性程度量表(IBS-SSS)、中医症状及IBS生活质量(IBS-QOL)评定,检测血清5-羟色胺(5-HT)及记录不良反应。[结果]IBS-SSS评分和临床疗效、中医辨证症状分级计分和临床疗效以及IBS-QOL评分比较,两组患者治疗后均优于治疗前(P<0.05);且组间比较显示,治疗组优于对照组(P<0.05)。2周后治疗组患者血清5-HT含量低于对照组(P<0.05)。两组均未出现不良反应。[结论]穴位埋线结合健脾疏肝法可有效降低肝郁脾虚证腹泻型肠易激综合征患者IBS-SSS及中医辨证症状分级计分,提高临床有效率及IBS-QOL评分,改善生活质量,同时降低血清5-HT含量,且无不良反应。[Objective]To explore the clinical effect and safety of acupoint embedding combined with strengthening the spleen and soothing the liver on irritable bowel syndrome-diarrheal(IBS-D)of liver depression and spleen deficiency.[Methods]The 40 patients with IBS-D(syndrome of liver depression and spleen deficiency)from April to June 2018 were randomly divided into treatment group(20 cases)and control group(20 cases).The control group was treated with Chinese medicine granules,2 bags one day,continuously for 2 weeks.On this basis,patients in the treatment group received acupoint embedding therapy once a week for 2 consecutive weeks.IBS-SSS,traditional Chinese medicine(TCM)symptoms and IBS-QOL were evaluated before and 2 weeks after treatment,and serum 5-HT was detected and adverse reactions were recorded.[Results]The comparison of IBS-SSS score and clinical efficacy,TCM symptom score and clinical efficacy,and IBS-QOL score showed that both groups were better after treatment than before(P<0.05),and the comparison between two groups showed that the treatment group was better than the control group(P<0.05).After 2 weeks,serum 5-HT content of patients in the treatment group was lower than that in the control group(P<0.05).No adverse reactions occurred in either group.[Conclusion]Acupoint embedding combined with liver soothing and anti-depression therapy can effectively reduce IBS-SSS and TCM symptom scores of patients with IBS-D of liver depression and spleen deficiency,improve clinical efficiency and IBS-QOL score,ameliorate quality of life,and reduce serum 5-HT content without adverse reactions.

关 键 词：穴位埋线 健脾疏肝 IBS-D 疗效观察 安全性评价 

分 类 号：R574.4[医药卫生—消化系统]