前列腺癌分子影像学诊断与治疗进展  

Advances in molecular imaging diagnosis and treatment of prostate cancer

作　　者：包森林 红华 BAO Senlin;HONG Hua(Inner Mongolia Medical University,Hohhot 010010,China;Department of Ultrasound Medicine,Inner Mongolia People's Hospital,Hohhot 010010,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010010 [2]内蒙古自治区人民医院超声医学科,内蒙古呼和浩特010010

出　　处：《分子影像学杂志》2021年第2期396-399,共4页Journal of Molecular Imaging

基　　金：内蒙古自治区科技计划项目(2019GG101)。

摘　　要：前列腺癌严重威胁着男性健康,近年来我国前列腺癌的发病率也迅速增加,早期发现前列腺癌对于提高生存率具有十分积极的意义。目前各前列腺癌指南中仍需通过超声引导下的前列腺活检确诊,再通过主动监测、根治性切除术、放疗及局部放疗等手段进行治疗。但前列腺活检增加了尿潴留、血尿等不必要的风险,还会遗漏多达1/3的癌组织,且目前的治疗方法因缺乏特异性而对患者进行过度或不足的治疗。近年来,对前列腺癌的诊断和治疗已经迈入分子水平,通过分子影像学进行无创精准的诊断和治疗展现出巨大的发展前景。本文将从核医学分子成像、MR分子成像、光学分子成像、超声分子成像4种常见分子影像学技术在前列腺癌的应用进展进行回顾并作一综述。Prostate cancer is a serious threat to men's health.In recent years,the incidence of prostate cancer in my country has also increased rapidly.Early detection of prostate cancer has a very positive significance for improving the survival rate.At present,the prostate cancer guidelines still need to be diagnosed by ultrasound-guided prostate biopsy,and then treated by means of active monitoring,radical resection,radiotherapy,and local radiotherapy.However,prostate biopsy increases unnecessary risks such as urinary retention,hematuria,and misses up to one-third of cancer tissues.The current treatment methods lack specificity and over-or under-treatment of patients.In recent years,the diagnosis and treatment of prostate cancer have entered the molecular level,and the non-invasive and accurate diagnosis and treatment of prostate cancer through molecular imaging has shown great development prospects.This article reviews and summarizes the application progress in prostate cancer of four common molecular imaging technologies,nuclear medicine molecular imaging,MR molecular imaging,optical molecular imaging,and ultrasound molecular imaging.

关 键 词：前列腺癌 分子影像诊断 靶向治疗 

分 类 号：R737.25[医药卫生—肿瘤]