帕金森病伴不宁腿综合征患者多导睡眠图的临床特征研究  

Clinical and polysomnography findings in patients with Parkinson’s disease with restless leg syndrome

作　　者：孙述昱 程金湘 邱健 任佳封 赵显超 吴成吉 宿长军 SUN Shuyu;CHENG Jinxiang;QIU Jian(Department of Neurology,The Second Affiliated Hospital of Air Force Military Medical University,Xi’an 710038,China)

机构地区：[1]空军军医大学第二附属医院神经内科,陕西西安710038 [2]空军军医大学基础医学院学员一大队二队,陕西西安710032

出　　处：《中风与神经疾病杂志》2021年第4期335-339,共5页Journal of Apoplexy and Nervous Diseases

基　　金：空军军医大学科技创新发展基金(2019XB041)。

摘　　要：目的评估帕金森病(Parkinson’s disease,PD)合并不宁腿综合征(Restless legs syndrome,RLS)患者(PD-RLS)与特发性不宁腿综合征(idiopathic restless legs syndrome,iRLS)之间的临床及睡眠特征差异及相关的影响因素。方法收集2015年-2020年收治的125例PD患者以及137例iRLS患者,并根据PD患者是否合并RLS分为PD伴RLS组(PD-RLS)和单纯PD(PD-NRLS)组,比较分析3组的一般状况、临床特征及主客观睡眠检查等的差异。结果PD患者共病RLS的患病率为27.2%。PD-RLS患者UPDRS-Ⅲ评分高于PD-NRLS。PD-RLS患者客观睡眠质量较iRLS患者更差,年龄和共病PD是RLS患者客观睡眠质量差的危险因素。IRLS-RS和HAMD评分是RLS患者主观睡眠质量差的危险因素。结论PD-RLS患者较iRLS患者更易出现客观睡眠障碍,而iRLS患者主观睡眠障碍更重,可能与RLS是否合并PD的临床异质性相关。Objective To evaluate the differences of clinical and sleep characteristics and related factors between patients with Parkinson’s disease(PD)with restless leg syndrome(RLS)and idiopathic restless leg syndrome(iRLS).Methods One hundred and twenty-five patients with PD and 137 patients with iRLS from 2015 to 2020 were collected.PD patients were divided into PD with RLS group(PD-RLS)and PD without RLS group(PD-NRLS).The general condition,clinical features,subjective and objective sleep examination of the three groups were compared and analyzed.Results The prevalence of comorbid RLS in PD patients was 27.2%.The score of UPDRS-Ⅲscore in patients with PD-RLS was higher than that in PD-NRLS.The objective sleep quality of patients with PD-RLS was worse than that of patients with iRLS.Age and comorbid PD were the risk factors of poor sleep quality in patients with RLS.IRLS-RS and HAMD scores are risk factors for poor subjective sleep quality in patients with RLS.Conclusion Objective sleep disorders are more likely to occur in patients with PD-RLS than in patients with iRLS.While subjective sleep disorders in patients with iRLS are more severe.Which may be related to the clinical heterogeneity of RLS complicated with PD.

关 键 词：帕金森病 不宁腿综合征 多导睡眠图 

分 类 号：R742.5[医药卫生—神经病学与精神病学]