血清活性氧簇、还原型谷胱甘肽水平与原发性胆汁性肝硬化的相关性分析  

The correlation between levels of serum ROS and GSH and primary biliary cirrhosis

作　　者：江小云[1] 陈科[1] 马思思 董家琪 JIANG Xiao-yun;CHEN Ke;MA Si-si;DONG Jia-qi(Department of Gastroenterology,Deyang People s Hospital,Deyang 618000,China)

机构地区：[1]四川省德阳市人民医院消化内科,四川德阳618000

出　　处：《实用医院临床杂志》2021年第3期149-152,共4页Practical Journal of Clinical Medicine

摘　　要：目的探讨血清活性氧簇(ROS)和还原型谷胱甘肽(GSH)水平与原发性胆汁性肝硬化(PBC)的相关性。方法我院收治的121例PBC患者(观察组)及同期接受体检的60例志愿者(健康对照组),收集临床资料,比较两组肝功能、肝纤维化指标及血清ROS、GSH水平。评估血清指标单独及联合检测对PBC的诊断价值。分析PBC患者血清ROS、GSH水平与相关生化指标之间的相关性。结果观察组ALT、AST、TBIL、HA、LN、PCⅢ、Ⅳ-C、血清ROS、GSH水平高于健康对照组,ALB水平低于健康对照组(P<0.05);血清ROS、GSH单独检测及联合检测诊断PBC的曲线下面积(AUC)分别为0.737、0.740、0.816,单独检测及联合检测血清ROS、GSH水平均可作为诊断PBC的效能指标(P<0.05);PBC患者血清ROS水平与ALT、AST、TBIL、HA、LN、PCⅢ、Ⅳ-C指标呈正相关(P<0.05),GSH水平与ALT、AST、HA、LN、PCⅢ、Ⅳ-C指标呈负相关(P<0.05)。结论血清ROS、GSH可能参与PBC的肝纤维化形成及肝功能损伤,可作为临床早期诊断的重要指标,具有一定临床意义。Objective To explore the correlation between levels of serum reactive oxygen species( ROS) and reduced glutathione( GSH) and primary biliary cirrhosis( PBC). Methods A total of 121 patients with PBCwho received treatment in our hospital were selected as observation group and 60 volunteers who received physical examinations during the same period were selected as healthy control group.Their clinical data were collected,and the liver function indicators,liver fibrosis indicators and levels of serum ROS and GSH were compared between the two groups.The diagnostic value of serum indicators alone and combined detection for PBC were evaluated.The correlation between levels of serum ROS and GSH and related biochemical indicators in patients with PBC was analyzed. Results The levels of ALT,AST,TBIL,HA,LN,PCIII and IV-C in the observation group were significantly higher than those in the healthy control group( P<0. 05) while the ALB level was significantly lower than that in healthy control group( P<0. 05).The levels of serum ROS and GSH in the observation group were significantly higher than those in the healthy control group( P<0. 05).ROC curve analysis showed that the areas under the curves( AUC) of serum ROS and GSH alone and combined detection for PBC were0. 737,0. 740 and 0. 816,respectively.Both individual detection and combined detection of serum ROS and GSH could be used as efficacy indicators for diagnosing PBC( all P<0. 05).Pearson correlation analysis showed that serum ROS level in patients with PBC was positively correlated with ALT,AST,TBIL,HA,LN,PCIII and IV-C( P< 0. 05) while GSH level was negatively correlated with ALT,AST,HA,LN,PCIII and IV-C( P < 0. 05). Conclusion Serum ROS and GSH may participate in the formation of liver fibrosis and liver function damage of PBC.They can be used as important indicators for early clinical diagnosis.It has a certain clinical significance.

关 键 词：活性氧簇 还原型谷胱甘肽 原发性胆汁性肝硬化 相关性 

分 类 号：R575.2[医药卫生—消化系统]