妊娠合并癫痫75例临床分析  

The clinical analysis of 75 cases of pregnancy with epilepsy

作　　者：黄春玉[1] 代荫梅[2] 高婉丽[1] 冯力民[1] HUANG Chunyu;DAI Yinmei;GAO Wanli;FENG Limin(Department of Obstetrics and Gynecology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院妇产科,100070 [2]首都医科大学附属北京妇产医院妇科,100070

出　　处：《中国妇产科临床杂志》2021年第2期150-152,共3页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的探讨妊娠合并癫痫患者的临床特点和诊治方法。方法回顾性分析2006年1月至2019年12月在北京天坛医院产科分娩的妊娠合并癫痫患者75例,产后随访6个月。按随机数字表法1:1比例抽取同期分娩未合并癫痫的患者75例为对照组。根据妊娠期癫痫发作频率、服用抗癫痫药物规律性进行分组,分析各组的临床资料。结果 (1)妊娠合并癫痫组贫血、妊娠期高血压疾病、胎膜早破、剖宫产率及产后出血发生率明显高于对照组(P <0.05);(2)妊娠合并癫痫频繁发作组与非频繁发作组的临床特征比较,差异无统计学意义(P>0.05);(3)妊娠合并癫痫组妊娠期规律服药组的妊娠期癫痫发作率明显低于未规律服药组(P <0.05),未规律服药组中有1例发生癫痫持续状态而死亡。结论妊娠合并癫痫患者更容易发生贫血、妊娠期高血压疾病、胎膜早破、剖宫产及产后出血等并发症,妊娠期需规律服药可降低癫痫发作。Objective To study the clinical characteristics and treatment of epilepsy during pregnancy. Methods Retrospective analysis was conducted on 75 cases of pregnant patients with epilepsy who delivered in Beijing Tiantan Hospital from January 2006 to December 2019, and followed up for 6 months after delivery, according to random number table method 1:1, 75 patients without epilepsy were selected as the control group. The groups according to the frequency of epilepsy during pregnancy and the regularity of taking antiepileptic drugs, were divided and the clinical data of each group were analyzed. Results(1) Anemia, hypertensive disease during pregnancy, premature rupture of membranes, cesarean section rate and incidence of postpartum hemorrhage in pregnancy combined with epilepsy group were significantly higher than those in control group(P < 0.05).(2) There was no significant difference in the clinical characteristics between the frequent epileptic group and the non-frequent epileptic group(P > 0.05).(3) The number of epileptic seizures in pregnancy combined with epilepsy group was significantly lower than that in the group without regular medication(P < 0.05), and there was one case of epileptic status and death in the group without regular medication. Conclusion Pregnancy patients with epilepsy are more prone to anemia, pregnancy hypertension, premature rupture of membranes, cesarean section and postpartum hemorrhage and other complications. Regular medication should be taken during pregnancy to reduce seizures.

关 键 词：妊娠 癫痫 临床特征 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R714.2[医药卫生—临床医学]