微小RNA与孤独症谱系障碍研究进展  

Research progress of the relationship between microRNAs and autism spectrum disorders

作　　者：孙志刚[1] 薛曼[1] 张红梅[1] 王斌[1] 李素水[1] Sun Zhigang;Xue Man;Zhang Hongmei;Wang Bin;Li Sushui(The Fifth Department of Psy chiatry,the Eighth Hospital of Shijiazhuang,Shijiazhuang 050000,China)

机构地区：[1]石家庄市第八医院精神五科,050000

出　　处：《神经疾病与精神卫生》2021年第3期213-217,共5页Journal of Neuroscience and Mental Health

基　　金：河北省科学技术研究与发展计划项目(152777223)。

摘　　要：孤独症谱系障碍(ASD)是一组严重的高异质性神经发育障碍,是遗传因素和复杂环境因素共同作用的结果,病理学机制还不清楚.大量的研究提示表观遗传学机制尤其是特殊脑区的miRNA表达异常可能参与了ASD的发生发展,循环miRNA有望成为早期诊断的生物学标志物.Autism spectrum disorder(ASD)is a group of severe and highly heterogeneous neurodevelopmental disorders,which is the result of a combination of genetic factors and complex environmental factors.The pathologic mechanisms are still unclear.A large number of studies suggest that epigenetic mechanisms,especially abnormal miRNA expression in specific brain regions,may be involved in the occurrence and development of ASD,and circulating miRNA is expected to be a biological marker for early diagnosis.

关 键 词：孤独症谱系障碍 微小RNA 表观遗传学 综述 

分 类 号：R749.94[医药卫生—神经病学与精神病学]