催产素在焦虑障碍相关疾病方面的研究进展  

Research progress of oxytocin in anxiety disorders related diseases

作　　者：史琦 周萌萌 彭淼[1] Shi Qi;Zhou Mengmeng;Peng Miao(The Second Psychological Clinic,Shengjing Hospital of China Medical University,Shervyang 110022,China)

机构地区：[1]中国医科大学附属盛京医院第二心理门诊,沈阳110022

出　　处：《神经疾病与精神卫生》2021年第3期218-222,共5页Journal of Neuroscience and Mental Health

摘　　要：适度的压力有利于个体的生存和发展,但当压力水平超出个体所能承受范围或者反复暴露于压力下,会导致慢性应激,出现社会功能障碍,增加精神疾病的风险,尤其是焦虑障碍相关疾病.目前,研究已经发现催产素能系统的失调与焦虑障碍相关疾病的发生和维持有关.现阐述催产素与焦虑障碍相关社会功能缺陷的关系、催产素在焦虑障碍相关疾病中的作用机制及相关研究进展与不足,希望有助于提高对焦虑障碍相关疾病的理解,为未来催产素系统的研究提供资料,开发以催产素治疗为基础的个体化预防及治疗策略.Moderate stress is beneficial to the survival and development of individuals.But it will lead to chronic stress,social dysfunction and increase the risk of mental illness,especially anxiety disorders and related disorders when the stress level beyond what an individual can bear or repeated exposure to stress.Current research has found that dysregulation of the oxytocinergic system is associated with the development and maintenance of anxiety related psychiatric disorders.This article describes the relationship between oxytocin(OXT)and anxiety disorder related social dysfunction,the mechanism of oxytocin in anxiety disorder related diseases,and the progress and deficiency of related research,hoping to help improve the understanding of anxiety disorder related diseases,provide information for the future research of oxytocin system,and develop individualized prevention and treatment strategies based on oxytocin treatment.

关 键 词：催产素 社会认知 焦虑障碍 社交恐惧 创伤后应激障碍 

分 类 号：R749.72[医药卫生—神经病学与精神病学]