一种稳定的薁磺酸钠漱口水新剂型的研究  

Search for the Prescription and Preparation Method of Sodium Azulene Sulfonate Powder

作　　者：高玉芹[1] 张辰辰[1] 孙媛[1] 安庆军[1] 秦旭荣 GAO Yu-qin;ZHANG Chen-chen;SUN Yuan;AN Qing-jun;QIN Xu-rong(Biomedical Engineering Center of Hebei Medical University,Shijiazhuang 050011,China)

机构地区：[1]河北医科大学生物医学工程中心,河北石家庄050011

出　　处：《海峡药学》2021年第4期1-3,共3页Strait Pharmaceutical Journal

摘　　要：目的探讨分析稳定的薁磺酸钠散剂处方及制备方法。方法在薁磺酸钠中分别加入抗氧剂茶多酚、BHT、维生素C,探索薁磺酸钠最佳抗氧剂。加入不同比例茶多酚,经加速和长期试验,筛选其最优添加量。结果经考察茶多酚为最佳抗氧剂。加速试验下,用量在0.25%时,对散剂的保护作用最佳;长期试验则为0.2%。结论茶多酚对薁磺酸钠散剂能够起到良好的抗氧化作用,处方中最佳用量为0.25%。OBJECTIVE Search for the prescription and the preparation method of stable sodium azulene sulfonate powder.METHODS To found a suitable antioxidant for sodium azulene sulfonate,tea polyphenol,BHT and vitamin C were added to sodium azulene sulfonate.To screen the optimal amount of tea polyphenol,tea polyphenol were added uo the sodium azulene sulfonate powder by accelerated test and long-term test.RESULTS Tea polyphenol was the best antioxidant.Under accelerated conditions,0.25%was a suitable amount to play a good protective role in the powder;uneer long-term conditions,tea polyphenol was 0.2%.CONCLUSION Tea polyphenol could exert a good antioxidant effect on sodium sulfonate preparations,and the suitable dosage was 0.25%in the prescription of sodium azulene sulfonate powder.

关 键 词：薁磺酸钠 茶多酚 口腔护理 稳定性 

分 类 号：R94[医药卫生—药剂学]