超声介导帕金森病治疗研究进展  

Recent advances in ultrasound-mediated treatment of Parkinson′s disease

作　　者：郭凯丽 刘亦晨[1] 李昕 王攀[1] GUO Kaili;LIU Yichen;LI Xin;WANG Pan(School of Life Sciences,Shaanxi Normal University,Xi′an 710119,Shaanxi,China)

机构地区：[1]陕西师范大学生命科学学院,陕西西安710119

出　　处：《陕西师范大学学报（自然科学版）》2021年第3期1-10,共10页Journal of Shaanxi Normal University：Natural Science Edition

基　　金：国家自然科学基金(81872497)。

摘　　要：帕金森病(Parkison′s disease,PD)是一种常见的神经系统退行性疾病,其发病机制复杂且尚不明确,药物和手术手段仍难以根治,加之人体血脑屏障的存在,大部分治疗性药物难以进入脑内病灶部位,严重影响帕金森病的临床治疗效果。近年来研究发现,超声不仅在无创神经调控中发挥着重要作用,还能联合微泡可逆性开放血脑屏障、靶向介导药物或基因局部递送,提高脑部治疗性药物的利用率。基于此,本文在介绍PD发病机制及其传统治疗手段的基础上,综述了近年来超声介导PD治疗研究的最新进展,包括超声开放血脑屏障在PD治疗中的应用潜能、超声直接用于PD治疗的情况以及超声介导的药物递送/基因递送/载体递送体系在PD治疗中的应用等,并提出未来超声在PD治疗中的研究方向,以期为开发PD临床高效治疗新途径提供思路。Parkison′s disease(PD)is a common degenerative disease of the nervous system.Its pathogenesis is complex and unclear,and it is still difficult to cure through traditional drugs and surgical methods.In addition,due to the existence of the blood-brain barrier(BBB),most therapeutic drugs are difficult to enter the lesions in the brain,which seriously weakened the clinical treatment effect of PD.In recent years,it has been found that ultrasound not only plays an important role in non-invasive neural regulation,but also can be combined with microbubbles to reversibly open the BBB,mediate the local delivery of drugs or genes to improve the utilization rates of therapeutic drugs in the brain.Based on the introduction of PD pathogenesis and its traditional treatment methods,this paper reviews the recent advances in ultrasound-mediated PD therapy,including the application potential of ultrasound in opening blood-brain barrier during PD treatment,the direct use of ultrasound in PD treatment,as well as the application of ultrasound mediated drug delivery/gene delivery/carrier delivery systems in PD treatment.Finally,the research direction of ultrasound in PD treatment in the future is proposed,so as to provide ideas for the development of new clinical effective treatment approaches of PD.

关 键 词：帕金森病 超声治疗 血脑屏障 靶向给药 

分 类 号：R742.5[医药卫生—神经病学与精神病学]