壳聚糖接枝物与琼脂复合膜的制备及性能研究  

Preparation and Properties of Composite Membrane of Chitosan Graft and Agar

作　　者：陈淑花[1] 岳丽春 张晶[1] 许利丽 詹世平[1] 王景昌[1] 张晓琳 CHEN Shu-hua;YUE Li-chun;ZHANG Jing;XU Li-li;ZHAN Shi-ping;WANG Jing-chang;ZHANG Xiao-lin(College of Environmental and Chemical Engineering,Dalian University,Dalian 116622,China)

机构地区：[1]大连大学环境与化学工程学院,辽宁大连116622

出　　处：《包装工程》2021年第1期77-82,共6页Packaging Engineering

基　　金：大连市科技创新基金(2018J12GX059)。

摘　　要：目的以琼脂(Agar)和壳聚糖-氧化微晶纤维素接枝物(CS-g-MCC(O))为原料制备海绵状薄膜,探究薄膜在医用敷料领域的应用。方法采用共混法将琼脂和壳聚糖-氧化微晶纤维素接枝物按不同体积比混合,然后使用冷冻干燥法制得薄膜,利用扫描电子显微镜对其多孔结构进行表征;对薄膜的溶胀率、溶失率、水蒸气透过率以及力学性能进行检测。结果制备出的海绵敷料形貌结构规整,有明显的孔洞,利于伤口排出代谢产物;随着琼脂含量的增加,海绵敷料的溶失率先减小后增加,溶胀率、孔隙率、透湿量、拉伸强度和断裂伸长率先增加后减小。结论海绵敷料各项性能都较为优异,有利于伤口渗出液的吸收和细胞生长,对伤口的愈合起到了重要作用,促进了其在医用敷料领域的应用。The work aims to prepare a spongy film with agar and chitosan-oxidized microcrystalline cellulose graft(CS-g-MCC(O)) as raw materials, and study the application of film in surgical dressing. The agar and chitosan-oxidized microcrystalline cellulose grafts were mixed in different proportions by blending method, and then the film was obtained by freeze-drying method, and the porous structure was characterized by scanning electron microscope;the swelling ratio, dissolution rate, water vapor transmission rate and mechanical properties of the film were tested. The prepared sponge dressing had regular morphological structure and obvious pores, which were helpful for the discharge of metabolites in the wound;with the increase of the agar content, the dissolution rate of the sponge dressing decreased first and then increased. The swelling ratio, porosity, moisture permeability, tensile strength and elongation at break increased first and then decreased. Sponge dressing is relatively excellent in all properties. These excellent properties are beneficial to the absorption of wound exudate and the growth of cells, which plays an important role in wound healing and promote its application in medical dressing.

关 键 词：琼脂 壳聚糖 氧化微晶纤维素 接枝 改性 海绵状敷料 

分 类 号：TB34[一般工业技术—材料科学与工程]