2型糖尿病患者糖抗原19-9升高的影响因素  

Influencing Factors of the Increase of Carbohydrate Antigens 19-9 in Type 2 Diabetes Mellitus

作　　者：刘诗琪[1] 吴瑶馨 LIU Shiqi;WU Yaoxin(The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;不详)

机构地区：[1]重庆医科大学附属第一医院,重庆400016

出　　处：《中外医学研究》2021年第10期180-182,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨2型糖尿病(T2DM)患者糖抗原19-9(CA19-9)升高的影响因素。方法:选取2019年1月-2020年3月在本院健康管理中心接受健康体检的193例T2DM患者作为研究对象。根据体检的血清CA19-9检出水平分为正常组(血清糖抗原19-9≤37 U/ml)和升高组(血清糖抗原19-9>37 U/ml),单因素分析CA19-水平升高的自变量,通过Logistic回归分析CA19-9水平升高的影响因素。结果:193例T2DM患者中,72例(37.31%)CA19-9水平升高(>37 U/ml),单因素分析结果显示升高组年龄、HbA1c、FBG、2 h PBG、CHOL、BMI值、视网膜病变及代谢综合征占比高于正常组,差异有统计学意义(P<0.05)。Logistic回归分析发现年龄增加、HbA1c、FBG、CHOL及BMI值升高、视网膜病变及代谢综合征皆是T2DM患者CA19-9水平升高的独立影响因素(P<0.05)。结论:HbA1c、FBG及CHOL与T2DM患者CA19-9水平升高密切相关,对于健康体检人群中T2DM患者应着重强调血糖、血脂水平的检测和控制,以预防CA19-9水平的持续或恶性升高。Objective:To investigate the factors influencing the increase of carbohydrate antigens 19-9 (CA19-9) in type 2 diabetes mellitus (T2DM).Method:A total of 193 T2DM patients who accepted physical examination at the healthy management center of the hospital from January 2019 to March 2020 were enrolled in this study,and divided into the normal group (CA19-9 ≤37 U/ml) and the elevated group (CA19-9 >37 U/ml) upon the CA19-9 level.Univariate analysis was performed to determine the independent variables for the increase of serum CA19-9 level.Logistic regression was used to analyze the influencing factors of CA19-9 level.Result:Among 193 T2DM patients,72 patients (37.31%) presented increase of CA19-9.Univariate analysis showed that the age,HbA1c,FBG,2 h PBG,CHOL,BMI,the proportion of retinopathy and metabolic syndrometics in the elevated group were higher than those in the normal group,and the differences were statistically significant (P<0.05).Logistic regression analysis showed that increasing age,HbA1c,FBG,CHOL,BMI,retinopathy and metabolic syndrome were the independent influencing factors to increase of CA19-9 (P<0.05).Conclusion:HbA1c,FBG and CHOL are closely related to increase of CA19-9 of T2DM patients,therefore,it should put emphasis on the detection and control of the levels of blood glucose and serum lipid so as to prevent continuous or malignant increase.

关 键 词：健康体检 2型糖尿病 糖抗原19-9 血脂 血糖 预测能力 

分 类 号：R587.1[医药卫生—内分泌]