Target prediction of Chrysanthemum morifolium against hepatocellular carcinoma  

作　　者：Gang-Gang Li Zhan-Fang Xie Yong-Jun Zhao Wan-Gao Li Guo-Feng Qi 

机构地区：[1]Department of Traditional Chinese Medicine,Anyang Vocational and Technical College,Anyang 475000,China [2]Department of Pharmacy,Anyang Tumor Hospital,Anyang 475000,China [3]Basic Medical College,Hebei University of Chinese Medicine,Shijiazhuang 050091,China

出　　处：《TMR Integrative Medicine》2021年第14期1-10,11,共11页TMR整合医学

基　　金：This work was supported by Anyang science and Technology development plan project in 2020(Project No.228).

摘　　要：A novel computational system was used to decipher the targets and mechanisms of Chrysanthemum morifolium against hepatocellular carcinoma.The putative target profile of Chrysanthemum morifolium against hepatocellular carcinoma was identified from Traditional Chinese Medicine Systems Pharmacology and DrugBank.Next,identification of the protein-protein interaction network of Chrysanthemum morifolium against hepatocellular carcinoma targets,and the identification of differentially expressed genes in hepatocellular carcinoma,relied on data from the NCBI database.Finally,Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were used to analyze the common targets.Forty-eight active compounds in Chrysanthemum morifolium were identified by Traditional Chinese Medicine Systems Pharmacology and DrugBank,and 71 differentially expressed genes were identified in the GEO database.Further,10 core target proteins were selected,including CYP1A1,ADRB2,ADRA1B,PGR,MAOB,SLC6A4,GABRA1,MAOA,NOS3 and PTGS2.These target genes were also found to be associated with pathways involved in adrenergic receptor activity and catecholamine binding.

关 键 词：Chrysanthemum morifolium Hepatocellular carcinoma Network pharmacology Adrenergic receptor activity Catecholamine binding 

分 类 号：R73[医药卫生—肿瘤]