齐拉西酮联合奥卡西平治疗精神分裂症急性期兴奋激越效果分析  

Analysis of the Effect of Ziprasidone Combined with Oxcarbazepine in the Treatment of Schizophrenia with Excitement and Agitation in the Acute Stage

作　　者：李晓青[1] LI Xiaoqing(Department of Psychiatry,the Fifth People's Hospital of Zibo City,Zibo,Shandong Province,255000China)

机构地区：[1]淄博市第五人民医院精神科,山东淄博255000

出　　处：《系统医学》2021年第6期46-48,共3页Systems Medicine

摘　　要：目的分析对精神分裂症急性期兴奋激越症状患者实施齐拉西酮联合奥卡西平治疗的效果。方法从2018年1月—2020年5月择取78例精神分裂症急性期兴奋激越症状患者,以就诊时间先后顺序分组,每组39例,对照组实施齐拉西酮治疗,研究组实施齐拉西酮联合奥卡西平治疗,对组间效果进行对照。结果研究组阳性和阴性症状量表兴奋因子(PANSS-EC)(11.1±3.2)分、外显攻击行为量表(MOAS)(4.1±1.5)分低于对照组,差异有统计学意义(t=5.706、3.581,P<0.05);治疗后研究组神经生长因子(26.9±3.2)μg/L、脑源性神经营养因子(11.4±1.2)μg/L、胶质源性神经营养因子(489.6±58.2)μg/L均高于对照组,差异有统计学意义(t=7.954、7.728、3.861,P<0.05);治疗后研究组白细胞介素-6(32.6±9.2)ng/L、白细胞介素-1β(42.2±9.1)ng/L、白细胞介素-12(5.4±1.5)ng/L、肿瘤坏死因子-α(23.5±6.6)ng/L均低于对照组,差异有统计学意义(t=3.054、3.059、3.030、3.463,P<0.05);研究组对不良反应15.4%与对照组25.6%相比,组间对比差异无统计学意义(χ^(2)=1.258,P>0.05)。结论对于精神分裂症急性期兴奋激越症状患者来说,齐拉西酮联合奥卡西平的应用可改善临床症状,使血清神经细胞因子得到改善,减轻炎症反应,具备较高安全性。Objective To analyze the effect of ziprasidone combined with oxcarbazepine in patients with schizophrenia with agitation symptoms in the acute stage.Methods From January 2018 to May 2020,78 patients with schizophrenia with acute excitement and agitation symptoms were selected,and they were divided into groups in the order of visit time.Each group was 39 patients.The control group was treated with ziprasidone and the study group was treated with ziprasidone.Cetone combined with oxcarbazepine was used to control the effects between groups.Results The scores of Positive and Negative Symptom Scale Excitatory Factor(PANSS-EC)(11.1±3.2)point and Explicit Aggressive Behavior Scale(MOAS)(4.1±1.5)points of the study group were lower than those of the control group,the difference was statistically significant(t=5.706,3.581,P<0.05).after treatment,the study group's nerve growth factor(26.9±3.2)μg/L,brain-derived neurotrophic factor(11.4±1.2)μg/L and glial-derived neurotrophic factor(489.6±58.2)μg/L were higher than those of the control group,the difference was statistically significant(t=7.954,7.728,3.861,P<0.05).After treatment,study group interleukin-6(32.6±9.2)ng/L,interleukin-1β(42.2±9.1)ng/L,interleukin-12(5.4±1.5)ng/L,tumor necrosis factor-α(23.5±6.6)ng/L were lower than the control group,the difference was statistically significant(t=3.054,3.059,3.030,3.463,P<0.05);the study group had 15.4%of adverse reactions compared with the control group 25.6%,the difference between the groups was to statistically significant(χ^(2)=1.258,P>0.05).Conclusion For patients with schizophrenia with excitement and agitation symptoms in the acute phase,the application of ziprasidone combined with oxcarbazepine can improve clinical symptoms,improve serum neurocytokines,reduce inflammation,and have high safety.

关 键 词：齐拉西酮 奥卡西平 精神分裂症 急性期 兴奋激越 

分 类 号：R749[医药卫生—神经病学与精神病学]