儿童外周神经母细胞性肿瘤临床病理与免疫治疗的研究进展  

Research advances of clinical pathology and immunotherapy of peripheral neuroblastic tumors in children

作　　者：韦侠 方园 王一真 Wei Xia;Fang Yuan;Wang Yizhen(Department of Pathology,Children’s Hospital of Anhui Province,Hefei 230051,China)

机构地区：[1]安徽省儿童医院病理科,合肥230051

出　　处：《中华小儿外科杂志》2021年第4期375-378,共4页Chinese Journal of Pediatric Surgery

基　　金：安徽省儿童医院2019年中青年优秀科技人才培养项目(19etyy008)。

摘　　要：外周神经母细胞性肿瘤(peripheral neuroblastic tumors,pNT)是儿童常见的肿瘤性疾病,其发病机制复杂。该肿瘤因其生物学异质性,临床表现、病理类型呈现多样化,预后因其危险度分层不同而差异巨大。传统的治疗方法对高危患儿效果不佳,对该病的研究一直是医学界的热点和难点。免疫治疗的出现在一定程度上改善了高危患儿的预后。本文就近年来对pNT的研究进展及热点,包括发病机制、病理类型、诊断、危险度分层、预后和免疫治疗进展等进行综述。Peripheral neuroblastic tumor(pNT)is a common tumorous disease in children and its pathogenesis is complicated.Due to its biological heterogeneity,tumor has diverse clinical manifestations and pathological types and its prognosis varies greatly on the basis of different risk stratifications.Traditional treatments are often ineffective for high-risk patients and researches on the disease have remained hot and difficult issues in medical circles.To some extent,the emergence of immunotherapy has improved the prognosis of high-risk patients.This review summarizes the advances and hotspots of pNT on researches of pathogenesis,pathological types,diagnosis,risk stratification,prognosis and immunotherapy.

关 键 词：神经节苷脂类 外周神经母细胞性肿瘤 抗GD2抗体 免疫治疗 

分 类 号：R739.4[医药卫生—肿瘤]