华蟾素联合化疗在食管癌中对人端粒逆转录酶表达的影响  

The Influence of Huachan Element Combined with Chemotherapy on the Expression of Human Telomerase Reverse Transcriptase in Esophageal Cancer

作　　者：杨柳 洪永贵[1] 胡彦伟 郭君兰[1] Yang Liu;Hong Yonggui;Hu Yanwei;Guo Junlan(Department of Medical Oncology,Anyang Tumor Hospital,Anyang 455000)

机构地区：[1]安阳市肿瘤医院肿瘤内科,安阳455000

出　　处：《数理医药学杂志》2021年第5期749-750,共2页Journal of Mathematical Medicine

摘　　要：目的:探讨华蟾素注射液联合化疗对食管癌患者人端粒逆转录酶表达影响并分析其意义。方法:采用RT-PCR法检测30例华蟾素联合化疗患者及30例单纯化疗患者外周血hTERT mRNA阳性表达率。结果:联合用药组外周血hTERT MRNA阳性率为53.3%(16/30),单纯化疗组为86.7%(26/30),联合用药组较化疗组明显降低(P<0.05)。结论:华蟾素联合化疗对食管癌患者人端粒逆转录酶表达有明显抑制作用,增强了抗肿瘤疗效,改善治疗预后。食管癌患者外周血hTERT mRNA表达水平的检测,有助于食管癌的早期诊断、肿瘤细胞微转移的诊断、近期疗效评估和预后判断。Objective:To investigate the effect of Huachan element injection combined with chemotherapy on human telomere reverse transcriptase expression in patients with esophageal cancer and analyze its significance.Methods:RT-PCR was used to detect the positive expression rate of hTERT mRNA in peripheral blood of 30 patients with Huachan element injection combined with chemotherapy and 30 patients with chemotherapy alone.Results:The positive rate of hTERT MRNA in peripheral blood was 53.3%(16/30)in the combination group and 86.7%(26/30)in the single chemotherapy group,which was significantly lower in the combination group than that in the chemotherapy group(P<0.05).Conclusion:Combined with chemotherapy,Huachan element can significantly inhibit the expression of human telomere reverse transcriptase in patients with esophageal cancer,enhance the anti-tumor effect and improve the prognosis of treatment.The detection of hTERT mRNA expression level in peripheral blood of patients with esophageal cancer is helpful for the early diagnosis of esophageal cancer,the diagnosis of tumor cell micrometastasis,the evaluation of short-term efficacy and the judgment of prognosis.

关 键 词：食管癌 华蟾素 化疗 人端粒逆转录酶表达 

分 类 号：R735.1[医药卫生—肿瘤]