基于TLR4/NF-κB/Snail1信号通路的槲皮素对糖尿病大鼠肾脏疾病的实验  

Experiment of Quercetin on Diabetic Nephropathy in Rats Based on TLR4/NF-κB/Snail 1 Signaling Pathway

作　　者：王兴红[1,2] 邓海峰 孙缦利[1,2] 韩坤 王丹萍[3] Wang Xinghong;Deng Haifeng;Sun Manli;Han Kun;Wang Danping(Luohe Medical College,Luohe 462000;Henan Special Medical Food Engineering Technology Research Center,Luohe 462000;Department of Endocrinology,Luohe First People's Hospital,Luohe 462000)

机构地区：[1]漯河医学高等专科学校,河南漯河462000 [2]河南省特医食品工程技术研究中心,河南漯河462000 [3]漯河市第一人民医院内分泌科,河南漯河462000

出　　处：《中阿科技论坛（中英文）》2021年第5期88-93,共6页China-Arab States Science and Technology Forum

基　　金：2018年度河南省高等学校青年骨干教师培养计划资助项目(2018GGJS258);河南省2017年度科技发展计划项目(科技攻关)(1721023610312);漯河医学高等专科学校校级科研项目(2020-LYZKYYB011)。

摘　　要：本文基于TLR4/NF-κB/Snail1信号通路,通过采用一次性腹腔注射链脲佐菌素建立糖尿病大鼠模型,随机分为正常对照组、糖尿病模型组、阳性对照组和槲皮素组并进行对比分析。实验结果表明:槲皮素对糖尿病大鼠的肾脏保护作用可通过调控肾脏TLR4/NF-κB/Snail1信号通路,减轻炎症反应抑制肾脏纤维化。Based on TLR4/NF-κB/snail 1 signaling pathway,diabetic rats were randomly divided into control group,diabetic model group,positive control group and quercetin group by intraperitoneal injection of streptozotocin.The results showed that quercetin could alleviate inflammatory reactions and inhibit renal fibrosis by regulating TLR4/NF-κB/snail 1 signaling pathway.

关 键 词：槲皮素 糖尿病肾病 TOLL样受体4 核因子-ΚB 锌指转录因子Snail1 

分 类 号：R77[医药卫生—眼科]