早期应用大剂量尿激酶溶栓治疗脑梗死的临床疗效  

Clinical effect of early treatment of cerebral infarction with high dose urokinase thrombolysis

作　　者：刘军 Liu Jun(Second People's Hospital of Huaihua City,Hunan Huaihua 418000)

机构地区：[1]怀化市第二人民医院,湖南怀化418000

出　　处：《中国社区医师》2021年第13期40-41,共2页Chinese Community Doctors

摘　　要：目的:探究早期应用大剂量尿激酶溶栓治疗脑梗死的临床疗效。方法:2019年8月-2020年8月收治脑梗死患者82例,随机分为两组,各41例。参照组给予常规治疗;试验组在常规治疗基础上给予大剂量尿激酶溶栓治疗。比较两组治疗前后神经功能缺损(NIHSS)评分、生活质量(QOL)评分、日常生活活动能力(barthel)指数及临床疗效。结果:试验组治疗1、2、4、7 d后的NIHSS评分均低于参照组,差异有统计学意义(P<0.05);试验组QOL评分、barthel指数及治疗总有效率均高于参照组,差异有统计学意义(P<0.05)。结论:脑梗死患者早期应用大剂量尿激酶溶栓,可逐渐改善神经功能缺损情况,有效提高日常活动能力及生活质量,提升临床疗效。Objective:To explore the clinical effect of early administration of large dose urokinase thrombolysis in the treatment of cerebral infarction.Methods:From August 2019 to August 2020,82 patients with cerebral infarction were selected and randomly divided into two groups with 41 patients in each group.The control group was given conventional treatment.The experimental group received high dose urokinase thrombolytic therapy on the basis of conventional treatment.Neurological deficit(NIHSS)score,quality of life(QOL)score,activity of daily living(barthel)index and clinical efficacy were compared between the two groups before and after treatment.Results:NIHSS scores of the experimental group were lower than the control group after 1,2,4 and 7 days of treatment,with the differences were statistically significant(P<0.05).QOL score,Barthel index and total effective rate in the test group were higher than the reference group,with the differences were statistically significant(P<0.05).Conclusion:Early administration of large dose urokinase thrombolysis in patients with cerebral infarction can gradually improve the neurological deficit,effectively improve the ability of daily activities and quality of life,and enhance clinical efficacy.

关 键 词：大剂量尿激酶 溶栓治疗 脑梗死 临床疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]