基因启动子甲基化与口腔鳞癌的研究进展  

Research progress of gene promoter methylation and oral squamous cell carcinoma

作　　者：贾玉良(综述) 陈彬 梁文红(审校) JIA Yuliang;CHEN Bin;LIANG Wenhong(Zunyi Medical University,Zunyi,Guizhou 563000,China;Affiliated Stomatological Hospital,Zunyi Medical University,Zunyi,Guizhou 563000,China;Special Key Laboratory of Oral Diseases Research,Guizhou Provincial General Institutes of Higher Education,Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医科大学,贵州遵义563000 [2]遵义医科大学附属口腔医院,贵州遵义563000 [3]贵州省普通高等学校口腔疾病研究特色重点实验室,贵州遵义563000

出　　处：《重庆医学》2021年第9期1596-1600,共5页Chongqing medicine

基　　金：国家863计划课题(2013AA102503);贵州省重点学科建设项目(黔学位合字ZDXK[2017]5号);贵州省遵义市红花岗区科学计划项目(遵红科合社字[2016]03号)。

摘　　要：口腔鳞癌(OSCC)是最常见的口腔恶性肿瘤,病死率高且预后差。近年来,越来越多的研究表明,表观遗传修饰特别是基因启动子甲基化在OSCC的发展中起到非常重要的作用。基因启动子甲基化可以调节OSCC抑癌基因的转录,并有望成为OSCC早期检测和治疗的生物标志物。本文就近5年研究热门的6个OSCC基因启动子甲基化的相关进展进行综述。Oral squamous cell carcinoma(OSCC)is the most common oral malignant tumor with high mortality rate and poor prognosis.In recent years,more and more studies reveal the epigenetic modification,especially gene promoter methylation,plays a very important role in the development of OSCC.The gene promoter methylation can regulate the transcription of tumor suppressor genes in OSCC,and is expected to become a biomarker for early detection and treatment of OSCC.This article reviews the related progress of promoter methylation of six hot OSCC genes in recent five years.

关 键 词：口腔鳞癌 表观遗传 启动子甲基化 治疗 生物标志物 

分 类 号：R780.1[医药卫生—口腔医学]