血府逐瘀汤联合亚低温对急性脑梗死动脉溶栓术后缺血再灌注损伤的保护作用研究  

Protective effect of Xuefu Zhuyu Decoction combined with mild hypothermia on ischemia-reperfusion injury in patients with acute cerebral infarction after arterial thrombolysis

作　　者：孙瑶[1] 李柏霖 胡楠 SUN Yao;LI Bo-lin;HU Nan(The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,China;General Hospital of Northern Theater Command of the Chinese People′s Liberation Army,Shenyang 110016,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034 [2]北部战区总医院,辽宁沈阳110016 [3]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《实用药物与临床》2021年第5期423-427,共5页Practical Pharmacy and Clinical Remedies

基　　金：辽宁省教育厅一般项目(L201907)。

摘　　要：目的探讨血府逐瘀汤联合亚低温对急性脑梗死(ACI)动脉溶栓术后缺血再灌注损伤的保护作用。方法将2017年6月至2019年6月在我院行动脉介入溶栓术的60例ACI患者随机分为对照组和试验组,每组30例。根据病情予动脉溶栓治疗及常规治疗,对照组予亚低温治疗,干预5~7 d。试验组加血府逐瘀汤,2次/d,治疗7 d。检测治疗前及治疗3、7 d后炎症因子IL-1β、IL-10、hs-CRP、SOD、MDA的变化,应用闪光视觉诱发电位无创检测颅内压,应用美国国立卫生院神经功能缺损量表(National Institutes of health neurological deficit scale,NIHSS)评估神经功能。比较两组临床疗效。结果与治疗前比较,治疗3、7 d后,两组IL-1β降低(P<0.05),IL-10、hs-CRP升高(P<0.05),SOD升高(P<0.05),MDA降低(P<0.05),NIHSS、ICP降低(P<0.05);与同时间对照组比较,治疗3、7 d后,试验组IL-1β、hs-CRP低于对照组(P<0.05),IL-10高于对照组(P<0.05),SOD高于对照组(P<0.05),MDA低于对照组(P<0.05),NIHSS、ICP低于对照组(P<0.05),总有效率高于对照组(P<0.05)。结论血府逐瘀汤联合亚低温对急性脑梗死动脉溶栓术后缺血再灌注损伤具有较好的保护作用。Objective To investigate the protective effect of Xuefu Zhuyu Decoction combined with mild hypothermia on ischemia-reperfusion injury in patients with acute cerebral infarction(ACI)after arterial thrombolysis.Methods From June 2017 to June 2019,60 patients with ACI underwent intra-arterial thrombolysis in our hospital,and they were randomly divided into control group and experimental group,30 cases in each group.The patients in both groups were treated with mild hypothermia for 5-7 days.The experimental group was also treated with Xuefu Zhuyu Decoction,twice a day for 7 days.The changes in inflammatory factors(IL-1β,IL-10),hs-CRP and oxidative stress factors(SOD,MDA)were detected before treatment and after 3 and 7 days of treatment.ICP was measured by flash visual evoked potential(VEP)and neurological function was assessed by NIHSS.The clinical effects were compared.Results Compared with before treatment,after 3 and 7 days of treatment,IL-10 and hs-CRP were increased(P<0.05),SOD was increased(P<0.05),MDA was decreased(P<0.05),and NIHSS and ICP were decreased(P<0.05);compared with the control group at the same time(at 3 and 7 days after treatment),IL-1βand hs-CRP in the experimental group were lower(P<0.05),IL-10 was higher(P<0.05),SOD was higher(P<0.05),MDA was lower(P<0.05),NIHSS and ICP were lower(P<0.05)and the total effective rate was higher(P<0.05).Conclusion Xuefu Zhuyu Decoction combined with mild hypothermia has a good protective effect on ischemia-reperfusion injury after arterial thrombolysis in acute cerebral infarction.

关 键 词：急性脑梗死 动脉溶栓术 血府逐瘀汤 亚低温 缺血再灌注损伤 

分 类 号：R743.33[医药卫生—神经病学与精神病学]