慢性乙型肝炎患者中医证型与凝血功能相关性研究  

The study on the relationship between Chinese medical syndrome types of chronic hepatitis B patients and coagulation function

作　　者：杨小蓉[1] 卢汉威[1] 秦建川 YANG Xiao-rong;LU Han-wei;QIN Jian-chuan(Department of Testing,First Affiliated Hospital of Guangdong Pharmaceutical University(Guangzhou,510080),China.)

机构地区：[1]广东药科大学附属第一医院检验科,广东广州510080

出　　处：《中西医结合肝病杂志》2021年第5期421-423,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：广州市科技计划项目(No.201803040014)。

摘　　要：目的:探讨慢性乙型肝炎(CHB)患者中医证型与凝血功能的相关性。方法:66例CHB患者按临床中医辨证分型分为湿热内结、肝郁脾虚、肝肾阴虚、瘀血阻络及脾肾阳虚证型5种,检测患者凝血功能,并分析各证型凝血指标的相关性。结果:血浆凝血酶原时间(PT):肝郁脾虚型与脾肾阳虚型患者差异有统计学意义(P<0.05);湿热内结型、瘀血阻络型及脾肾阳虚型患者与对照组比较差异有统计学意义(P<0.05)。凝血酶原活动度(PT-A):脾肾阳虚型与湿热内结型及肝郁脾虚型患者比较差异有统计学意义(P<0.05),湿热内结型、肝肾阴虚型、瘀血阻络型及脾肾阳虚型患者与对照组比较差异有统计学意义(P<0.05)。PT国际标准化比值(PT-INR):脾肾阳虚型与湿热内结型及肝郁脾虚型患者比较差异有统计学意义(P<0.05),瘀血阻络型及脾肾阳虚型患者与对照组比较,差异有统计学意义(P<0.05)。活化部分凝血活酶时间(APTT):瘀血阻络型与肝郁脾虚型、肝肾阴虚型患者比较差异有统计学意义(P<0.05),瘀血阻络型患者与对照组比较,差异有统计学意义(P<0.05)。纤维蛋白原含量(FIB):湿热内结型与瘀血阻络型患者比较,差异有统计学意义(P<0.05)。结论:PT、PT-A、PT-INR、APTT、FIB检测可作为CHB中医辨证分型的参考指标。Objective:To explore the relationship between Chinese medical syndrome types of chronic hepatitis B patients and coagulation function,as plasma prothrom time(PT),prothrombin activity(PT-A),international standardized radio(INR),activated partial thromboplastin time(APTT),fibrinogen content(FIB)and thrombin time(TT).Methods:Totally 66 hepatitis B patients were syndrome typed as damp heat internal knot(DHIK),gan depression Pi deficiency syndrome(GDPDS),gan-shen yin deficiency syndrome(GSYDS),static blood blocking collaterals syndrome(SBBCS),and Pi-Shen yang deficiency syndrome(PSYDS),coagulation function were detected with STA-R evolution automatic coagulator.Results:There was a significant difference in the result of PT between liver depression and spleen deficiency and spleen kidney yang deficiency(P<0.05).There was a significant difference in the result of PT compared DHIK and SBBCS and PSYDS with the healthy control group(P<0.05).The was no significant difference between GDPDS and GSYDS with the healthy control group(P>0.05).Comparison of the results of PT-A of various syndrome types:there was statistical significance between SBBCS,DHIK,and GDPDS(P<0.05).There was statistical significance between DHIK and GSYDS and PSYDS and SBBCS with the health control group(P<0.05),but there was no significant difference between GDPDS with the health control group(P>0.05).Comparison of the results of PT-INR of various syndrome types:there was statistical significance compared PSYDS with DHIK with GDPDS(P<0.05).There was statistical significance between SBBCS and PSYDS with the healthy control group(P<0.05),but there was no significant difference between DHIK and GDPDS and GSYDS with the healthy control group(P>0.05).Comparison of APTT results of various syndrome types:there was statistical sig nificance between the SBBCS and GDPDS and GSYDS(P<0.05).There was statistical significance between the results SBBCS with the results of the healthy control group(P<0.05),while there was no significant difference between the results of

关 键 词：慢性乙型肝炎 中医证型 凝血功能 

分 类 号：R735[医药卫生—肿瘤]