安多霖胶囊对老年鼻咽癌放疗病人炎症因子及外周血单核细胞凋亡的影响  

Effects of andolin capsule on inflammatory factors and apoptosis of peripheral blood mononuclear cells in elderly patients with nasopharyngeal carcinoma undergoing radiotherapy

作　　者：夏宏娟 袁芳[1] 美丽姑 邹蕴 XIA Hong-juan;YUAN Fang;MEI Li-gu;ZOU Yun(Department of Radiotherapy, Urumchi General Hospital of Xinjiang Military Region, Urumchi 830000, China)

机构地区：[1]中国人民解放军新疆军区乌鲁木齐总医院放疗科,新疆维吾尔自治区乌鲁木齐市830000

出　　处：《实用老年医学》2021年第5期467-469,474,共4页Practical Geriatrics

基　　金：兰州军区科学基金项目(CLZ15JB07)。

摘　　要：目的探讨安多霖胶囊对老年鼻咽癌放疗病人炎症因子IL-6和TNF-α水平及外周血单核细胞凋亡的影响。方法收集2019年1~12月就诊于新疆军区乌鲁木齐总医院肿瘤放疗科,病理诊断明确为鼻咽癌,年龄>65岁的病人共计40例。按照随机数字表法,分为安多霖胶囊治疗组20例,对照组20例。2组病人放疗方案相同,治疗组加用安多霖胶囊4粒/次、3次/d口服至放疗结束。观察2组病人口腔黏膜炎发生情况以及放疗前后血清中IL-6、TNF-α水平和外周血单核细胞凋亡率。结果入组时2组口腔黏膜炎严重度分布差异无统计学意义(P>0.05);放疗后对照组病人口腔黏膜炎分级较治疗组更严重(P<0.05)。入组时2组血清IL-6、TNF-α水平,外周血单核细胞凋亡率水平比较差异无统计学意义(P>0.05);放疗后对照组血清IL-6、TNF-α水平,外周血单核细胞凋亡率均高于治疗组(P<0.05)。结论安多霖胶囊可以有效控制老年鼻咽癌病人放疗过程中的口腔黏膜炎的进展,其作用机制可能是通过对病人TNF-α、IL-6水平的调节和外周血单核细胞的保护实现的。Objective To investigate the effect of andolin capsule on the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)and the apoptosis of peripheral blood mononuclear cells in the elderly patients with nasopharyngeal carcinoma(NPC)undergoing radiotherapy.Methods From January to December 2019,a total of 40 patients with NPC over 65 years old were enrolled in the Department of Cancer Radiotherapy.According to the random number table,all the cases were divided into two groups the treatment group(20 cases)and the control group(20 cases).The two groups had the same radiotherapy plan.The treatment group added 4 capsules of andolin capsule three times a day until the end of radiotherapy.The incidence of oral mucositis,the levels of IL-6,TNF-αand the apoptosis rate of peripheral blood mononuclear cells were observed.Results There was no significant difference in the severity of oral mucositis between the two groups before radiotherapy(P>0.05).After radiotherapy,the severity degree of oral mucositis in the control group was worse than that in the treatment group(P<0.05).There were no significant differences in the levels of serum IL-6,TNF-αand the apoptosis rate of peripheral blood mononuclear cells between the two groups before treatment(P>0.05).The levels of serum IL-6 and TNF-αand the apoptosis rate of peripheral blood mononuclear cells in the control group were higher than those in the treatment group after treatment(P<0.05).Conclusions Andolin capsule can effectively reduce the progression of oral mucositis in the elderly patients with NPC during radiotherapy.The mechanism may be associated with the regulation of TNF-αand IL-6 levels and the protection of peripheral blood mononuclear cells.

关 键 词：安多霖胶囊 老年人 鼻咽癌 放疗 炎症因子 细胞凋亡 

分 类 号：R739.63[医药卫生—肿瘤]