小窝相关蛋白在乳腺癌中作用的研究进展  

Research progress of caveolae-related proteins in human breast cancer

作　　者：汪百川 余岳 李颖曦 葛洁 田垚(审校) WANG Bai-chuan;YU Yue;LI Ying-xi;GE Jie;TIAN Yao(Anhui Chest Hospital,Anhui Medical University Clinical College of Chest,Hefei 230022,China;Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin,Key Laboratory of Breast Cancer Prevention and Therapy,Ministry of Education,Tianjin Medical University;Department of Pathogen Biology,School of Basic Medical Sciences,Tianjin Medical University;Department of General Surgery,Tianjin Medical University General Hospital)

机构地区：[1]安徽省胸科医院,安徽医科大学临床学院,230022 [2]天津医科大学肿瘤医院,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,乳腺癌防治教育部重点实验室 [3]天津医科大学基础医学院病原生物学系 [4]天津医科大学总医院普通外科

出　　处：《天津医药》2021年第5期556-560,共5页Tianjin Medical Journal

摘　　要：小窝及其相关蛋白与乳腺癌的发生发展密切相关。小窝外壳蛋白包括Cav-1、Cav-2及Cav-3,其中Cav-1最受关注,其作为抑癌及促癌因子影响乳腺癌细胞的增殖、凋亡、迁移、侵袭以及转移。Cav-2也具有抑癌及促癌双重作用,其既可与Cav-1结合共表达,也可独自发挥调控作用。Cav-3在乳腺癌中研究较少,其表达缺失可形成抗肿瘤微环境。小窝接头蛋白(Cavins)包括Cavin-1、Cavin-2、Cavin-3及Cavin-4。Cavin-1可抑制Cav-1诱导的细胞膜小管形成,其在乳腺癌中发挥的具体作用仍存争议。Cavin-2作为乳腺癌抑制因子,可通过阻断转化生长因子(TGF)-β信号通路,抑制乳腺癌进展。Cavin-3在乳腺癌中发挥抑癌功能,而其具体作用机制尚不清楚。Cavin-4与乳腺癌间关系尚不明确。Caveolae and its related proteins are closely related to the occurrence and development of breast cancer.Caveolins include Cav-1,Cav-2 and Cav-3,among which Cav-1 is the most concerned.According to different molecular types and stages of breast cancer,Cav-1 play a dual role as tumor suppressor and tumor promoter and affect cell proliferation,apoptosis,migration,invasion and metastasis of tumor.Cav-2 can also inhibit and promote cancer.Cav-2 can not only cooperate with Cav-1,but also play a regulatory role independently.At present,Cav-3 is less studied in breast cancer.Alblation of Cav-3 can form an anti-tumor microenvironment.Cavins include Cavin-1,Cavin-2,Cavin-3 and Cavin-4.Cavin-1 can inhibit membrane tubule formation induced by Cav-1,and its specific role in breast cancer remains controversial.As a breast cancer suppressor,Cavin-2 can inhibit the progression of breast cancer by blocking TGF-β signaling pathway.Cavin-3 plays an anti-tumor role in breast cancer,but its specific mechanism is still unclear.The relationship between Cavin-4 and breast cancer is still not clear.

关 键 词：乳腺肿瘤 膜蛋白质类 细胞质膜微囊蛋白 肿瘤转移 Cavins 

分 类 号：R737.9[医药卫生—肿瘤]