喹硫平与利培酮治疗老年精神障碍疗效及安全性比较  

Comparison of the efficacy and safety of quetiapine and risperidone in the treatment of elderly mental disorders

作　　者：李红[1] 李方捷[1] 马燕[1] 毛叶萌[1] LI Hong;LI Fangjie;MA Yan(Department of Pharmacy,Mental Health Center Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心药剂科,上海市200030

出　　处：《临床合理用药杂志》2021年第10期9-12,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：上海医院药学科研项目(No:2017-YY-02-05)。

摘　　要：目的比较喹硫平与利培酮治疗老年精神障碍的疗效及安全性。方法选择2017年7月-2019年4月上海交通大学医学院附属精神卫生中心收治的老年精神障碍患者90例,按患者入院的时间顺序分为喹硫平组和利培酮组,每组45例。喹硫平组给予富马酸喹硫平片治疗,利培酮组给予利培酮片治疗。比较2组临床疗效,治疗前和治疗第2、4、6、8周神经精神科问卷(NPI)、临床疗效总评量表(CGI)、精神科药物不良反应量表(UKU)评分,不良反应。结果 2组临床治疗总有效率比较差异无统计学意义(χ^(2)=0.073,P=0.788)。治疗前,2组NPI评分、CGI-SI评分比较差异均无统计学意义(P>0.05);治疗第2、4、6、8周,2组NPI评分、CGI-SI评分均低于治疗前,且喹硫平组CGI-SI评分低于利培酮组(P<0.05),2组NPI评分比较差异均无统计学意义(P>0.05);治疗第2、4、6、8周,喹硫平组CGI-GI评分高于利培酮组(P<0.05)。2组不良反应总发生率比较差异无统计学意义(χ^(2)=2.182,P=0.140)。结论喹硫平与利培酮治疗老年精神障碍均有较好的疗效,喹硫平不良反应总发生率较低,程度较轻。Objective To compare the efficacy and safety of quetiapine and risperidone in the treatment of senile mental disorders. Methods A total of 90 elderly patients with mental disorders admitted to the Mental Health Center Affiliated to Shanghai Jiaotong University School of Medicine from July 2017 to April 2019 were selected and divided into quetiapine group and risperidone group according to the time sequence of admission,with 45 patients in each group. The quetiapine group was treated with quetiapine fumarate tablets,and the risperidone group was treated with risperidone tablets. The clinical efficacy,neuropsychiatric questionnaire(NPI),general clinical efficacy scale(CGI),psychiatric adverse drug reaction scale(UKU) score before treatment and 2,4,6 and 8 weeks after treatment,adverse reactions were compared between the two groups. Results There was no significant difference in the total effective rate of clinical treatment between the two groups(χ^(2)= 0. 073,P = 0. 788). Before treatment,there were no significant difference in NPI score and CGI-SI score between the two groups(P > 0. 05);at 2,4,6 and 8 weeks of treatment,the NPI score and CGI-SI score of the two groups were all lower than before treatment,and the CGI-SI score of the quetiapine group was lower than that of the risperidone group(P< 0. 05),there was no significant difference in the NPI score between the two groups(P > 0. 05). 2,4,6 and 8 weeks after treatment,the CGI-GI score of the quetiapine group was higher than that of the risperidone group(P< 0. 05). Conclusion Both quetiapine and risperidone have good efficacy in the treatment of senile mental disorders. The total incidence of quetiapine adverse reactions is low and the degree is mild.

关 键 词：喹硫平 利培酮 精神障碍 老年 疗效 安全性 

分 类 号：R749[医药卫生—神经病学与精神病学]