齿垢密螺旋体与龈下菌斑微生物相互作用的研究进展  

Research progress in the interaction between Treponema denticola and microorganisms of subgingival plaque

作　　者：黄培恩 申道南 吴亚菲[1] Huang Peien;Shen Daonan;Wu Yafei(Department of Periodontics,West China Hospital of Stomatology,Sichuan University&State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院牙周病科口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心,成都610041

出　　处：《中华口腔医学杂志》2021年第4期380-384,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81771077)。

摘　　要：齿垢密螺旋体是与牙周病发生发展密切相关的一类革兰阴性厌氧微生物,在成熟牙菌斑中占比较高。作为龈下菌斑生物膜的晚期定植者,齿垢密螺旋体与更早期的定植者及同期定植者之间存在复杂的相互作用关系,这些相互作用包括共生关系,以及群体感应分子调控下的协同与拮抗作用。黏附与共聚是这些相互作用的基础,由一系列表面分子介导。这种相互作用最终表现为代谢、毒力方面的基因表达改变,以代谢改变为主,涉及多种氨基酸代谢相关酶的上调或下调。本文就齿垢密螺旋体与龈下菌斑微生物相互作用的相关研究作一综述。Treponema denticola(Td)is a gram-negative anaerobic bacterium closely related to the occurrence and development of periodontal disease and it accounts for a considerable proportion of mature plaque.As a later colonizer of the subgingival plaque biofilm,Td may have complex interactions with earlier and concurrent colonists including symbiotic relationship as while as synergistic or antagonistic effects under the regulation of quorum sensing molecules.Adhesin and coaggregation,mediated by a series of surface molecules,are the basis of the interaction.These interactions are ultimately manifested as gene expression changes in metabolism and virulence,in which are mainly metabolism changes with up-or down-regulation of multiple enzymes related to amino acid metabolism.This article reviews the related researches on the interaction between Td and microorganisms of subgingival plaque.

关 键 词：齿垢密螺旋体 共生 群体感应 黏附与共聚 代谢改变 

分 类 号：R781.42[医药卫生—口腔医学]