Neuromodulatory therapies for patients with prolonged disorders of consciousness  

作　　者：Yue-Hao Wu Jie Yu Li-Rong Hong Ben-Yan Luo 

机构地区：[1]Department of Neurology,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang 310003,China [2]Department of Neurology,First People’s Hospital of Yuhang District,Hangzhou,Zhejiang 310003,China [3]Department of Rehabilitation,Hangzhou Hospital of Zhejiang Armed Police Corps,Hangzhou,Zhejiang 310051,China.

出　　处：《Chinese Medical Journal》2021年第7期765-776,共12页中华医学杂志（英文版）

基　　金：National Natural Science Foundation of China(No.81870817);Fundamental Research Funds for the Central Universities(No.2019-XZZX-001-01-02);Key Realm R&D Program of Guangzhou(No.202007030005)。

摘　　要：Background:Reviving patients with prolonged disorders of consciousness(DOCs)has always been focused and challenging in medical research.Owing to the limited effectiveness of available medicine,recent research has increasingly turned towards neuromodulatory therapies,involving the stimulation of neural circuits.We summarised the progression of research regarding neuromodulatory therapies in the field of DOCs,compared the differences among different studies,in an attempt to explore optimal stimulation patterns and parameters,and analyzed the major limitations of the relevant studies to facilitate future research.Methods:We performed a search in the PubMed database,using the concepts of DOCs and neuromodulation.Inclusion criteria were:articles in English,published after 2002,and reporting clinical trials of neuromodulatory therapies in human patients with DOCs.Results:Overall,187 published articles met the search criteria,and 60 articles met the inclusion criteria.There are differences among these studies regarding the clinical efficacies of neurostimulation techniques for patients with DOCs,and large-sample studies are still lacking.Conclusions:Neuromodulatory techniques were used as trial therapies for DOCs wherein their curative effects were controversial.The difficulties in detecting residual consciousness,the confounding effect between the natural course of the disease and therapeutic effect,and the heterogeneity across patients are the major limitations.Large-sample,well-designed studies,and innovations for both treatment and assessment are anticipated in future research.

关 键 词：Disorders of consciousness NEUROMODULATION THERAPY 

分 类 号：R749.1[医药卫生—神经病学与精神病学]