二肽基肽酶样蛋白-6抗体相关脑炎临床诊治进展  

Advances in the diagnosis and treatment of dipeptidyl-peptidase-like protein 6 antibody- associated encephalitis

作　　者：理二闯 章殷希[1] 丁美萍[1] Li Erchuang;Zhang Yinxi;Ding Meiping(Department of Neurology,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院附属第二医院神经内科,杭州310009

出　　处：《中华神经科杂志》2021年第4期424-428,共5页Chinese Journal of Neurology

摘　　要：二肽基肽酶样蛋白-6(DPPX)抗体相关脑炎是一种由血清和(或)脑脊液中DPPX抗体介导的新型自身免疫性脑炎,临床表现具有异质性,体重下降和(或)胃肠功能障碍(主要为腹泻)、认知-精神异常和中枢神经过度兴奋三联征为本病的典型表现,脑磁共振成像多无特异性改变,免疫治疗可改善症状但容易复发。Dipeptidyl-peptidase-like protein 6(DPPX)antibody-associated encephalitis,mediated by DPPX antibodies in serum and/or cerebrospinal fluid,is a novel autoimmune encephalitis.It presents with multifocal and diverse neurological disorders characterized by the triad of prodromal weight loss and/or gastrointestinal symptoms(diarrhea predominately),cognitive-mental dysfunction,and central nervous system hyperexcitability.Brain magnetic resonance imaging shows non-specific abnormalities.Immunotherapy can result in clinical improvements,but the disease is prone to relapse.

关 键 词：脑炎 腹泻 二肽基肽酶样蛋白-6抗体 过度惊骇 

分 类 号：R742.9[医药卫生—神经病学与精神病学]