红藤棱莪方治疗湿热血瘀型反流食管炎的效果及对食管压力的改善作用  

Effect of Using Hongteng Ling’e Recipe in the Treatment of Damp-heat and Blood-stasis Type Reflux Esophagitis and its Improvement on Esophageal Pressure

作　　者：杨振华[1] 曹会杰[2] 黄傲霜[1] 殷泙[3] YANG Zhenhua;CAO Huijie;HUANG Aoshuang(Departmentof Spleen and Stomach Diseases,Longhua Hospital Atached to Shanghai University of Traditional Chinese Medicine,Shanghai200032,China;Department of Traditional Chinese Medicine,Putuo District Central Hospital,Shanghai 200062,China)

机构地区：[1]上海中医药大学附属龙华医院脾胃病科,上海200032 [2]上海市普陀区中心医院中医内科,上海200062 [3]上海中医药大学附属岳阳中西医结合医院消化科,上海200437

出　　处：《四川中医》2021年第4期102-106,共5页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察中医方剂联合西医基础疗法治疗湿热血瘀型反流食管炎患者的临床效果。方法选取我院收治的118例反流性食管炎患者作为研究对象,采用前瞻性随机试验设计将患者分为中西医组和西医组各59例,两组患者均给予基础的埃索美拉唑、枸缘酸莫沙必利进行治疗,中西医组同时服用红藤棱莪方治疗,疗程8周;对比治疗前后两组患者的中医证候积分、内镜下反流性食管炎评分、血清白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)、食管压力测定结果、临床疗效、不良反应发生率。结果:治疗后,中西医组患者的反酸、烧心、脘腹胀闷、口渴少饮、便溏不爽、恶心呕吐、口干口苦、舌苔、舌质评分均低于西医组(P<0.05);治疗前两组患者的内镜下评分差异无统计学意义(P>0.05);治疗后,中西医组患者的内镜下评分均低于西医组(P<0.05);两组患者治疗前后的血清IL-1β、IL-8水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的血清IL-8水平较治疗前均降低(P<0.05),两组患者之间差异无统计学意义(P>0.05);治疗前,中西医组和西医组的食管下括约肌静息压、下括约肌松弛率、下段蠕动波压力测定结果比较,差异无统计学意义(P>0.05);治疗后,中西医组的食管下括约肌静息压高于西医组(P<0.05);两组患者下括约肌松弛率、下段蠕动波压力测定结果之间比较,差异无统计学意义(P>0.05);中西医组的痊愈率3.51%、显效率59.65%、有效31.58%、无效5.26%,西医组的痊愈率1.72%、显效率43.10%、有效44.83%、无效10.34%,中西医组的疗效有效优于西医组(P<0.05)。结论中医方剂联合西医基础疗法治疗湿热血瘀型反流食管炎能更有效的缓解临床症状,食管下压力,对于提高临床疗效具有一定的临床价值。Objective:To explore the clinical effect of traditional Chinese medicine combined with western medicine basic therapy in treating patients with damp-heat and blood-stasis type reflux esophagitis.Methods:The 118 patients with reflux esophagitis admitted to our hospital were selected as the research objects.The prospective randomized trial design was used to divide the patients into the Chinese and western medicine group and the western medicine group with 59 cases each.Both groups were given basic esomeprazole,Mosapride Citrate was used for treatment,and the Chinese and western medicine group was treated with Hongteng Ling’e Decoction at the same time for 8 weeks;the TCM syndrome scores,endoscopic reflux esophagitis score,and serum white blood cells of the two groups before and after treatment Interleukin-1β(IL-1β),interleukin-8(IL-8),esophageal pressure measurement results,clinical efficacy,and incidence of adverse reactions.Results:After treatment,the scores of acid reflux,heartburn,abdominaldistension,thirst,loose stools,nausea and vomiting,dry mouth,bitter mouth,tongue coating,and tongue quality in the TCM group were lower than those in the western medicine group(P<0.05);there was no significant difference in the endoscopic scores of the two groups before treatment(P>0.05);after treatment,the endoscopic scores of the Chinese and western medicine groups were lower than those of the western medicine group(P<0.05);there was no significant difference in serum IL-1βand IL-8 levels(P>0.05);after treatment,the serum IL-8 levels of the two groups were lower than before treatment(P<0.05).The difference was not statistically significant(P>0.05);before treatment,there was no statistically significant difference in the measurement results of the lower esophageal sphincter resting pressure,lower sphincter relaxation rate,and lower peristaltic wave pressure in the traditional Chinese and western medicine group and the Western medicine group(P>0.05).After treatment,the resting pressure of the lower esophageal sphincter

关 键 词：中医 反流性食管炎 红藤棱莪方 湿热血瘀型 

分 类 号：R573[医药卫生—消化系统]