血清HMGB-1 MIF PDGF预测急性脑出血短期预后的临床价值  

Clinical Value of Serum HMGB-1 MIF and PDGF in Predicting Short-Term Prognosis of Acute Cerebral Hemorrhage

作　　者：骆金轮 吴非 祝东强[1] 刘进[1] LUO Jinlun;WU Fei;ZHU Dongqiang(Chengdu Fifth People's Hospital, Sichuan Chengdu 611130, China)

机构地区：[1]四川省成都市第五人民医院,四川成都611130

出　　处：《河北医学》2021年第5期785-789,共5页Hebei Medicine

基　　金：四川省卫生厅科研项目,(编号:130259)。

摘　　要：目的:分析血清高迁移率族蛋白-1(HMGB-1)、巨噬细胞移动抑制因子(MIF)、血小板源生长因子(PDGF)预测急性脑出血短期预后的临床价值。方法:回顾性分析2016年05月至2020年05月我院收治的106例急性脑出血患者的临床资料,根据神经系统损害程度分为轻度组(NIHSS 1~4分,n=23)、中度组(NIHSS 5~20分,n=53)及重度组(NIHSS>20分,n=30),同时选取同期于本院进行体检的40例健康者作为对照组,3个月后根据格拉斯哥评分(GOS)分为预后良好组(GOS 4~5分,n=60)和预后不良组(GOS≤3分,n=46),检测血清HMGB-1、MIF、PDGF水平,采用ROC曲线下面积(AUC)分析HMGB-1、MIF、PDGF预测急性脑出血近期预后的临床价值。结果:轻度组、中度组、重度组血清HMGB-1、MIF、PDGF水平高于对照组(P<0.05),重度组血清HMGB-1、MIF、PDGF水平高于轻度组和中度组,中度组血清HMGB-1、MIF、PDGF水平高于轻度组(P<0.05);预后良好组血清HMGB-1、MIF、PDGF水平低于预后不良组(P<0.05);血清HMGB-1、MIF、PDGF水平联合检测的敏感度及AUC面积均高于单独检测(P<0.05)。结论:血清HMGB-1、MIF、PDGF对急性脑出血短期预后预测价值较高,可用于治疗指导。Objective:To analyze the clinical value of serum high mobility group protein-1(HMGB-1),macrophage migration inhibitory factor(MIF)and platelet-derived growth factor(PDGF)in predicting short-term prognosis of acute cerebral hemorrhage.Methods:Clinical data of 106 patients with acute cerebral hemorrhage who were treated in the hospital between May 2016 and May 2020 were retrospectively analyzed.According to the severity of nervous system damage,the patients were divided into mild group(NIHSS 1~4 points,n=23),moderate group(NIHSS 5~20 points,n=53)and severe group(NIHSS>20 points,n=30).Meanwhile,40 healthy controls were made the control group.Three months later,according to the Glasgow Outcome Score(GOS),the patients were divided into favorable prognosis group(GOS 4~5 points,n=60)and bleak prognosis group(GOS≤3 points,n=46).Serum HMGB-1,MIF and PDGF levels were detected,and their clinical value in predicting short-term prognosis of acute cerebral hemorrhage was analyzed with the area under the ROC curve(AUC).Results:Serum HMGB-1,MIF and PDGF levels were higher in patients with cerebral hemorrhage than the control group(P<0.05),higher in the severe group than the mild and moderate groups,higher in the moderate group than the mild group(P<0.05),and higher in the favorable prognosis group than the bleak prognosis group(P<0.05).The sensitivity and AUC area of serum HMGB-1,MIF and PDGF were higher than those of single detection(P<0.05).Conclusion:Serum HMGB-1,MIF and PDGF have high value in predicting short-term prognosis of acute cerebral hemorrhage,which can be used for treatment guidance.

关 键 词：急性脑出血 短期预后 高迁移率族蛋白-1 巨噬细胞移动抑制因子 血小板源生长因子 

分 类 号：R73[医药卫生—肿瘤]