甲状旁腺激素在骨软骨组织中的应用进展  

Progress of parathyroid hormone on bone and cartilage tissues

作　　者：陈玉书[1] 谢慧峰 张燕红 白波[1] 陈艺[1] 张姝江[1] Chen Yushu;Xie Huifeng;Zhang Yanhong;Bai Bo;Chen Yi;Zhang Shujiang(Department of Orthopaedic Surgery, Orthopedics Implantation Key Lab of Guangdong Province, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China;Department of Orthopaedic Surgery, Shunde Hospital of Southern Medical University, Foshan 528300, China)

机构地区：[1]广州医科大学附属第一医院广东省骨科矫形与植入材料重点实验室,510120 [2]南方医科大学顺德医院创伤关节外科,佛山528300

出　　处：《中华关节外科杂志（电子版）》2021年第2期214-218,共5页Chinese Journal of Joint Surgery(Electronic Edition)

基　　金：广东省教育厅特色创新类项目(2017KTSCX154)。

摘　　要：甲状旁腺激素(PTH)是亲骨性内分泌激素之一,参与多种细胞生物学过程。目前已有研究表明PTH可能通过多种信号通路参与骨形成,并可抑制软骨细胞的肥大分化及凋亡,刺激其增殖,从而可适度保护软骨细胞。本文通过对PTH在骨软骨组织的作用机制的研究进展进行综述。Parathyroid hormone(PTH)is one of the osteophilic endocrine hormones,which is involved in a variety of cellular biological processes.Previous studies have shown that PTH can inhibit the hypertrophic differentiation and apoptosis of chondrocytes and stimulate their proliferation,which has a moderate protection function on the cartilage cells by multiple signal pathways.In this paper,the mechanism of PTH in osteochondral tissue was reviewed.

关 键 词：甲状旁腺激素 成骨细胞 骨质疏松 软骨 间质干细胞 

分 类 号：R73[医药卫生—肿瘤]