乳腺导管原位癌伴微小浸润临床病理分析  

Breast ductal carcimona in situ with microinvasion: a clinicopathological analyses of nine cases

作　　者：李栋连 孙春杰 王晓晶 LI Dong-lian;SUN Chun-jie;WANG Xiao-jing(Department of Pathology,Tongzhou Maternal and Child Heath Hospital,Beijing 101110,China)

机构地区：[1]通州区妇幼保健院病理科,北京101110

出　　处：《诊断病理学杂志》2021年第4期281-284,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的总结和分析乳腺导管原位癌伴微小浸润(DCIS-MI)的临床病理学特点、诊断与鉴别诊断及预后。方法回顾分析9例乳腺DCIS-MI的临床特征,观察其组织病理学表现并对部分病例补做免疫组化,同时收集随访资料和相关文献。结果 9例乳腺DCIS-MI中,最大浸润灶直径≤0.1 cm;8例为高级别导管原位癌,1例为中级别导管原位癌;3例为粉刺型,管腔内均可见坏死,细胞核呈中/高级别。免疫组化:c-rebB-2(+) 7例,其中1例为(2+),6例为(3+)。经36个月的随访无一例发生复发和转移。结论乳腺DCIS-MI是一种比较少见的乳腺癌亚型,免疫组化c-rebB-2(+)和肌上皮标记物有助于诊断和鉴别诊断。本病很少发生复发及转移,预后很好。Objective To discuss the clinical,histopathological characteristics,diagnosis and differential diagnosis,and prognosis of breast ductal carcimona in situ( DCIS-MI). Methods Relative clinical features and histological changes were reviewed in nine cases of breast ductal caicimona in situ. Immunohistochemical stains were carried out in part cases.Relative literatures and follow-up data were reviewed. Results All of the 9 cases of DCIS-MI showed micro-invasive lesions with maximum size of < 0. 1 cm;8 cases were high grade dutal carcimona in situ,and 1 cases were intermediate grade ductal carcimona in situ. 3 cases were comedo type and demonstrated necrosis, and cell nuclei presented intermediate/high dysplasia. C-erbB-2 was positive in 8 cases,in which 1 case was moderately and 6 cases strongly positive. No patients had local recurrence and distant metastasis after a median follow-up of 36 months. Conclusion DCIS-MI is a less common type of breast carcinoma. C-erbB-2 and myoepithelial markers contribute to its differential diagnosis. Only few cases have local recurrence and distant metastasis with extremely good prognosis.

关 键 词：乳腺肿瘤 乳腺导管原位癌 微小浸润 病理学 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]