羟考酮控释片在肺癌患者中的应用研究  

Application of oxycodone controlled release tablets in patients with lung cancer

作　　者：邓丽群 DENG Liqun(Department of Medical Oncology,Guixi People's Hospital,Yingtan,Jiangxi,335400,China)

机构地区：[1]贵溪市人民医院肿瘤内科,江西鹰潭335400

出　　处：《当代医学》2021年第15期27-30,共4页Contemporary Medicine

摘　　要：目的探讨羟考酮控释片在肺癌患者中的应用效果。方法回顾性分析2017年1月至2020年4月本院收治的80例肺癌患者的临床资料,将采用盐酸吗啡缓释片治疗的患者作为对照组(n=41),将采用羟考酮控释片治疗的患者作为观察组(n=39)。比较两组治疗前、治疗2周时癌痛程度[视觉模拟评分法(VAS)]、生命质量[癌症患者生命质量测定量表(EORTC QLQ-C30)]、心理状态[抑郁自评量表(SDS)]及用药后不良反应发生情况(嗜睡、头晕、呕吐、厌食、便秘、呼吸抑制、排尿困难)。结果治疗后,两组VAS评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组生理功能、角色功能、情绪功能、认知功能、社会功能、总健康状况评分均高于治疗前,且观察组上述评分均高于对照组,差异有统计学意义(P<0.05);两组疲乏感、恶心呕吐、疼痛、气促、睡眠困难、食欲丧失、便秘、腹泻、经济困难评分均低于治疗前,且观察组上述评分均低于对照组,差异有统计学意义(P<0.05);治疗后,两组SDS评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率(17.95%)低于对照组(39.02%),差异有统计学意义(P<0.05)。结论羟考酮控释片治疗可减轻肺癌患者的疼痛程度,改善生命质量,缓解不良情绪,且安全性较高,值得推广应用。Objective To explore the application effect of oxycodone controlled-release tablets in patients with lung cancer.Methods The clinical data of 80 patients with lung cancer admitted to our hospital from January 2017 to April 2020 were retrospectively analyzed.Patients treated with morphine hydrochloride sustained-release tablets were set as the control group(n=41),patients treated with oxycodone controlled-release tablets were set as the observation group(n=39).The degree of cancer pain[visual analogue scoring(VAS)],quality of life[EORTC QLQ-C30],and psychological statu[selfrating depression scale(SDS)]before treatment and two weeks after treatment and adverse reactions(drowsiness,dizziness,vomiting,anorexia,constipation,respiratory depression,dysuria)after medication were compared between the two groups.Results After treatment,the VAS scores of the two groups were lower than those before treatment,and the scores of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05).After treatment,the scores of physiological function,role function,emotional function,cognitive function,social function,and total health status of the two groups were higher than those before treatment,and the scores of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).The scores of fatigue,nausea and vomiting,pain,shortness of breath,dyscoimesis,loss of appetite,constipation,diarrhea,and economic difficulties in the two groups were lower than those before treatment,and the scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the SDS scores of the two groups were lower than before treatment,and the scores of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(17.95%)was lower than that in the contr

关 键 词：肺癌 癌性疼痛 盐酸吗啡缓释片 羟考酮控释片 癌痛程度 生命质量 

分 类 号：R730.5[医药卫生—肿瘤] R734.2[医药卫生—临床医学]