Kruppel样因子家族在恶性肿瘤中的研究进展  

Research progress of Kruppel-like factor family in malignant tumors

作　　者：郑智 丁乙轩 梅文通 郭玉霖 曲元旭 卢炯地 刘爽[1] 孙海晨[1] 曹锋[1] 李非[1] Zheng Zhi;Ding Yixuan;Mei Wentong;Guo Yulin;Qu Yuanxu;Lu Jiongdi;Liu Shuang;Sun Haichen;Cao Feng;Li Fei(Department of General Surgery,Xuan Wu Hospital,Capital Medical University,Clinical Center for Acute Pancreatitis,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院普通外科,首都医科大学急性胰腺炎临床诊疗及研究中心,100053

出　　处：《国际外科学杂志》2021年第4期264-268,共5页International Journal of Surgery

基　　金：国家自然科学基金(81272756);北京市自然科学基金(7162076);北京市科技重大专项(Z171100001017077);北京市医管局扬帆计划(XMLX201404);北京市科学技术委员会首都临床诊疗技术研究及示范应用(Z191100006619038);首都医科大学临床医学高精尖学科建设项目(1192070312)。

摘　　要：恶性肿瘤早期多无明显临床症状,多数患者就诊时已处于进展期,部分患者丧失了手术机会,导致患者远期预后差。因而,针对此类患者如何能够找到最佳的治疗靶点,进而改善患者预后逐渐成为学者们关注的焦点。近年来,Kruppel样因子(KLF)作为一种可以结合目的DNA的转录调节因子,被证实在恶性肿瘤的发生、发展过程中发挥重要作用,也被证实KLF家族影响肿瘤细胞的增殖、分化和迁移,但是具体机制尚不完全清楚。因此,为进一步探讨KLF家族对于肿瘤的影响,本研究拟通过对KLF家族在细胞增殖、分化、迁移等方面的作用及调控机制作一简要综述,期望为恶性肿瘤的生物学治疗提供新靶点。Malignant tumors usually have no obvious clinical symptoms in the early stage.Most patients are already in the advanced stage when they are diagnosed.Some patients have lost the opportunity for operation,resulting in poor prognosis.Therefore,how to find the best therapeutic target for such patients and improve the prognosis of patients has gradually become the focus of scholar′s attention.Recently,Kruppel-like factor(KLF)is a transcriptional regulator that can bind to the target DNA,and its family plays an important role in the occurrence and development of malignant tumors.It has also been confirmed that the KLF family affects the proliferation,differentiation and migration of tumor cells,but the specific mechanism is still not fully elucidate.Consequently,in order to further explored the effect of the KLF family on tumors,this study intends to briefly review the roles and regulatory mechanisms of the KLF family in the cell proliferation,differentiation and migration of malignant tumors,hoping to provide new target for the biological treatment of tumors.

关 键 词：肿瘤 转录因子 Kruppel样因子 恶性肿瘤 调控机制 

分 类 号：R730.2[医药卫生—肿瘤]