对结肠癌肝转移患者不同治疗方案效果评价的网状meta分析  

A reticular meta‑analysis of the evaluation of the therapeutic effect of different treatment methods on colon cancer patients with liver metastasis

作　　者：郭云童[1] 熊永强 崔潇龙[1] 黄河[1] Guo Yuntong;Xiong Yongqing;Cui Xiaolong;Huang He(Department of General Surgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China;Department of General Surgery,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710000,Shannxi,China)

机构地区：[1]山西医科大学第一医院胃肠外科,太原030001 [2]西安交通大学第二附属医院普通外科,西安710004

出　　处：《肿瘤代谢与营养电子杂志》2021年第1期48-53,共6页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：山西省卫生健康委科研课题(2018037)。

摘　　要：目的评价4种治疗方案对结肠癌肝转移患者生存情况的影响。方法通过检索PubMed、EMBASE、Cochrane Library、中国学术期刊网络出版总库、维普中文科技期刊全文数据库、中国生物医学文献数据库、万方数据期刊论文资源、中国科学引文数据库和中国中医药等数据库,临床试验注册机构网站和Google学术、百度学术等检索相关文献获取全身化疗、术前化疗+手术+术后化疗、手术+术后化疗、手术+术后化疗+射频消融4种治疗方案治疗结肠癌肝转移的临床研究,根据纳入标准与排除标准对文献进行筛选并提取数据,采用Jadad工具评价文献质量,采用stata及GeMTC软件进行网状meta分析,发表偏倚采用漏斗图法、Begg′s Test及Egger′s Test评价,纳入相关之间的异质性评价利用Q检验和I2指数进行检验。结果最后共纳入10项研究,4种治疗方式,1026例受试者。网状meta分析结果显示,4种治疗方案中术前化疗+手术+术后化疗的治疗后第1年、第3年、第5年患者生存人数最高。结论在生存人数评价中,术前化疗+手术+术后化疗临床效果均优于其他3种治疗方案。Objective To evaluate the effects of four treatment options on the survival of patients with liver metastases from colon cancer.Methods Through searching PubMed,EMBASE,Cochrane Library,China Scientific Journals Network Publishing Library Weipu Chinese Science and Technology Journal Full-text Database,China Biomedical Literature Database,Wanfang Data Journal Paper Resources,China Scientific Citation Database and China Traditional Chinese Medicine Database,Clinical Trial Registration Institution Website and Google Academic Baidu Academic and other databases were searched for relevant literatures to obtain systemic chemotherapy,preoperative chemotherapy+surgery+postoperative chemotherapy,a clinical study on the treatment of liver metastases from colon cancer with four treatment options:surgery+postoperative chemotherapy,surgery+postoperative chemotherapy+radiofrequency ablation.According to the inclusion criteria and exclusion criteria,the literature was screened and data were extracted.The quality of the literature was evaluated using Jadad tools,and stata was used.Net⁃like meta⁃analysis was performed with GeMTC software,and the publication bias was evaluated by funnel plot method,Begg′s Test and Egger′s Test,and the evaluation of heterogeneity among the included correlations was tested by Q test and I2 index.Results A total of 10 studies,4 treatments,and 1026 subjects were included.The results of the net⁃like meta⁃analysis showed that the number of patients who survived the first year,the third year,and the fifth year after the treatment of preoperative chemotherapy+surgery+postoperative chemotherapy was the highest among the four treatment options.Conclusion In the evaluation of the number of survivors,the clinical effects of preoperative chemotherapy+surgery+postoperative chemotherapy are better than the other three treatment options.

关 键 词：肝转移 结肠癌 治疗方案 网状meta分析 

分 类 号：R735.35[医药卫生—肿瘤]