辅助生殖技术在葡萄胎治疗中的应用及研究进展  

Application of Assisted Reproductive Technology in Hydatidiform Mole

作　　者：杨婧祎 刘岩[2] 智旭(审校) YANG Jing-yi;LIU Yan;ZHI Xu(Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China;Department of Pathology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院妇产科生殖医学中心,100191 [2]北京大学第三医院病理科,100191

出　　处：《国际生殖健康／计划生育杂志》2021年第3期209-215,共7页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(81671458,81971440);国家重点研发计划“生殖健康及重大出生缺陷防控研究”专项(2018YFC1002302)。

摘　　要：葡萄胎(hydatidiform mole)是一种临床上较常见的产科疾病,属于妊娠滋养细胞疾病,主要特征是绒毛水肿变性。现阶段葡萄胎的诊断和分类主要通过临床表现和组织学检查。但是,葡萄胎分类复杂且病因不清楚,且复发性葡萄胎再发风险较高,很难预防。随着测序技术的发展,辅助生殖技术,尤其是胚胎植入前遗传学检测,近年来得到了飞速发展,可以应用于体外获取胚胎并予以评估。然而,由于现阶段对葡萄胎这一疾病了解的局限性,辅助生殖技术在葡萄胎患者中的应用依旧较局限。对于有生育要求的葡萄胎患者,特别是复发性葡萄胎患者,建议给予再生育指导。综述葡萄胎的流行病学、临床表现、组织病理学以及遗传学特点,并探讨辅助生殖技术在复发性葡萄胎中的应用进展。Hydatidiform mole(HM)is a common obstetric disease,which is classified as a gestational trophoblastic disease.HM is characterized by swollen villi.HM can be diagnosed and classified by clinical manifestations and histological examination.However,the complex classification and limitations of etiological knowledge of HM,in addition to the high risk of recurrence,make it difficult to prevent.With the development of sequencing technology,the assisted reproductive technology has been rapidly developed in recent years,especially the pre-implantation genetic testing.These technologies can be applied in the acquisition and evaluation of embryos in vitro.However,the application of assisted reproductive technology in HM patients is still confined due to the limitations of current understanding on HM.There are very limited knowledge on the prevention and reproductive guidance of HM,especially the recurrent HM.The epidemiology,clinical manifestations,histology and the genetic characteristics were reviewed in this article,while the application progress of assisted reproductive technology in HM was also discussed.

关 键 词：葡萄胎 妊娠滋养细胞疾病 NLR蛋白质类 生殖技术 辅助 突变 

分 类 号：R737.33[医药卫生—肿瘤]