宫颈癌根治术前介入化疗对手术疗效、肿瘤细胞凋亡、术后生活质量的影响  

Effect of preoperative interventional chemotherapy on the therapeutic effect,tumor apoptosis and quality of life of cervical cancer patients

作　　者：王斌[1] 张圳妙 全毅[1] 胥琳璟[1] 张月桃 洪苑[1] WANG Bin;ZHANG Zhenmiao;QUAN Yi;XU Linjing;ZHANG Yuetao;HONG Yuan(Department of Obstetrics and Gynecology,The First People′s Hospital of Zhaoqing,Zhaoqing 526020,China)

机构地区：[1]广东省肇庆市第一人民医院妇产科,广东肇庆526020

出　　处：《沈阳医学院学报》2021年第3期221-224,共4页Journal of Shenyang Medical College

基　　金：肇庆市科技创新指导类项目(No.201904030902)。

摘　　要：目的:探讨宫颈癌根治术前介入化疗对手术疗效、肿瘤细胞凋亡、术后生活质量的影响。方法:选取2013年1月至2016年6月收治的50例宫颈癌患者,随机分为观察组和对照组,各25例。2组患者均接受宫颈癌根治术,观察组术前给予介入化疗,对照组未进行。对比观察组介入化疗前后肿瘤最大径的变化。对比2组患者的手术情况、手术前后血清血管内皮生长因子(VEGF)、术后宫颈组织的肿瘤细胞凋亡相关指标的水平。对比2组患者术后的癌症患者生命质量量表(FACT-G)评分和术后3年的复发率、存活率。结果:观察组介入化疗后的肿瘤最大径显著小于介入化疗前(P<0.05)。观察组手术时间、术中出血量、淋巴结转移率显著低于对照组(P<0.05);术后VEGF-A、VEGF-C、VEGF-D显著低于对照组(P<0.05);天门冬氨酸蛋白水解酶-3(Caspase-3)、天门冬氨酸蛋白水解酶-9(Caspase-9)显著高于对照组,而肿瘤坏死因子α诱导蛋白-8(TNFAIP8)、过氧化物还原酶-4(Prdx4)显著低于对照组(P<0.05);2组患者术后FACT-G评分对比,差异无统计学意义(P>0.05);观察组术后3年的肿瘤复发率显著低于对照组(P<0.05);术后3年存活率高于对照组,但差异无统计学意义(P>0.05)。结论:宫颈癌术前介入化疗可促进肿瘤细胞凋亡,降低术后复发率,且对患者术后生活质量无明显不良影响。Objective:To investigate the effect of preoperative interventional chemotherapy on the therapeutic effect,tumor apoptosis and quality of life of cervical cancer patients.Methods:A total of 50 cases of cervical cancer from Jan 2013 to Jul 2016 were randomly divided into the observation group and the control group,25 cases in each group.Both groups received radical hysterectomy of cervical cancer.The observation group also received preoperative interventional chemotherapy,while the control group did not.The change of the maximum diameter of tumor before and after interventional chemotherapy in the observation group was compared.The operative indexes,the level of vascular endothelial growth factor(VEGF)before and after operation,and the level of tumor apoptosis related indexes in cervical tissue were compared between the two groups.The FACT-G score,recurrence rate and survival rate at 3 years after operation were compared between the two groups.Results:The maximum diameter of tumor in the observation group after interventional chemotherapy was significantly smaller than that before interventional chemotherapy(P<0.05).The operation time,intraoperative blood loss and lymph node metastasis rate in the observation group were significantly lower than those in the control group(P<0.05).After operation,the levels of VEGF-A,VEGF-C and VEGF-D in the observation group were significantly lower,the levels of Caspase-3 and Caspase-9 were significantly higher,and the levels of TNFAIP8 and Prdx4 were significantly lower than those in the control group(P<0.05).The FACT-G scores after operation between the two groups had no significant difference(P>0.05).The recurrence rate in the observation group at 3 years after operation was significantly lower than that in the control group(P<0.05),and the the survival rate was higher,but the difference was not statistically significant(P>0.05).Conclusion:Preoperative interventional chemotherapy for cervical cancer can promote the tumor apoptosis,reduce the recurrence rate,and has no significan

关 键 词：宫颈癌 介入化疗 肿瘤细胞凋亡 生活质量 

分 类 号：R737.33[医药卫生—肿瘤]